Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 12/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.68 |
| ▸ | THRB | P10828 | 1/20 | 0.68 |
| ▸ | NPC1 | O15118 | 6/20 | 0.67 |
| ▸ | RAB9A | P51151 | 6/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | TP53 | P04637 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 4/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | MITF | O75030 | 1/20 | 0.55 |
| ▸ | XBP1 | P17861 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22480888 | 0.90 | MRGPRX4 (0.74) | MRGPRX4SMN1; SMN2THRBNPC1RAB9A | |
| SCHEMBL26162589 | 0.86 | MRGPRX4 (0.77) | MRGPRX4SMN1; SMN2THRB | |
| SCHEMBL4502608 | 0.85 | MRGPRX4 (1.00) | MRGPRX4SMN1; SMN2THRBNPC1RAB9A | |
| SCHEMBL15235340 | 0.85 | MRGPRX4 (0.70) | MRGPRX4SMN1; SMN2THRBNPC1RAB9A | |
| SCHEMBL559537 | 0.83 | NOTUM (0.58) | MRGPRX4SMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL15227963 | 0.82 | MRGPRX4 (0.66) | MRGPRX4SMN1; SMN2THRBNPC1RAB9A | |
| SCHEMBL22469980 | 0.82 | MRGPRX4 (1.00) | MRGPRX4 | |
| SCHEMBL692883 | 0.82 | MRGPRX4 (0.66) | MRGPRX4SMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL6438620 | 0.81 | MRGPRX4 (0.58) | MRGPRX4SMN1; SMN2THRBNPC1RAB9A | |
| SCHEMBL9368856 | 0.81 | MRGPRX4 (0.74) | MRGPRX4SMN1; SMN2NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090325956-A1 | Aromatic amine derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325956-A1 | Aromatic amine derivative and use thereof | SCD, SCD5, SMS | MRGPRX4 1550/4885SMN1; SMN2 2075/4885THRB 2175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.