Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.57 |
| ▸ | MAPK13 | O15264 | 12/20 | 0.57 |
| ▸ | MAPK12 | P53778 | 12/20 | 0.57 |
| ▸ | MAPK11 | Q15759 | 12/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.51 |
| ▸ | CDK8 | P49336 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4504333 | 0.92 | MAPK14 (0.58) | MAPK14MAPK13MAPK12MAPK11RECQL | |
| SCHEMBL4078830 | 0.88 | CDK8 (0.59) | MAPK14MAPK13MAPK12MAPK11RECQL | |
| SCHEMBL1012616 | 0.88 | MAPK13 (0.66) | MAPK14MAPK13MAPK12MAPK11RECQL | |
| SCHEMBL1013743 | 0.87 | MAPK14 (0.73) | MAPK14MAPK13MAPK12MAPK11RECQL | |
| SCHEMBL378957 | 0.87 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11JAK2 | |
| SCHEMBL4210703 | 0.87 | MAPK14 (0.50) | MAPK14MAPK13MAPK12MAPK11RECQL | |
| SCHEMBL4204467 | 0.87 | MAPK14 (0.50) | MAPK14MAPK13MAPK12MAPK11RECQL | |
| SCHEMBL1013690 | 0.86 | MAPK13 (0.59) | MAPK14MAPK13MAPK12MAPK11RECQL | |
| SCHEMBL1793950 | 0.85 | MAPK14 (0.58) | MAPK14MAPK13MAPK12MAPK11RECQL | |
| SCHEMBL1012997 | 0.85 | MAPK14 (0.66) | MAPK14MAPK13MAPK12MAPK11JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090270350-A1 | Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives | PFIZER INC. | 2009-10-29 | — | — | US | disclosed |
| US-20090270350-A1 | Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives | PFIZER INC. | 2009-10-29 | — | — | US | disclosed |
| EP-1987022-A1 | PYRIDINONE PYRAZOLE UREA AND PYRIMIDINONE PYRAZOLE UREA DERIVATIVES | Pfizer Products Inc. (US) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007091176-A1 | PYRIDINONE PYRAZOLE UREA AND PYRIMIDINONE PYRAZOLE UREA DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2007-08-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270350-A1 | Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives | PDXK, UMPS, CDK2 | MAPK14 117/4885MAPK13 130/4885MAPK12 178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.