SCHEMBL451062

SCHEMBL451062

Cc1ccc(-c2nnco2)cc1-c1ccc(NC(=O)c2c(F)cccc2F)nc1

nearest known ligand 0.62

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
IL2 P60568 15/20 0.62
ABL1 P00519 3/20 0.46
RAF1 P04049 1/20 0.43
BRAF P15056 1/20 0.43
CREBBP Q92793 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2814582 0.88 IL2 (0.49) IL2ABL1
SCHEMBL4764238 0.87 IL2 (0.66) IL2RAF1BRAFCREBBP
SCHEMBL2816312 0.86 IL2 (0.50) IL2
SCHEMBL2817751 0.85 IL2 (0.69) IL2ABL1
SCHEMBL2814805 0.84 IL2 (0.53) IL2RAF1BRAF
SCHEMBL2813178 0.83 IL2 (0.64) IL2ABL1
SCHEMBL5029396 0.83 IL2 (0.48) IL2
SCHEMBL8239294 0.82 IL2 (0.67) IL2ABL1
SCHEMBL2816403 0.82 IL2 (0.65) IL2ABL1
SCHEMBL5550955 0.82 IL2 (0.64) IL2CREBBP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 86 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140187586-A1 PYRIDYLPHENYL COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES SYNTA PHARMACEUTICALS CORP. (US) 2014-07-03 US claimed
US-8710083-B2 Pyridylphenyl compounds for inflammation and immune-related uses SYNTA PHARMACEUTICALS CORP. (US) 2014-04-29 US claimed
EP-1984338-B1 PYRIDYLPHENYL COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES SYNTA PHARMACEUTICALS CORP (US) 2013-01-16 EP claimed
US-20100249195-A1 PYRIDYLPHENYL COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES SYNTA PHARMACEUTICALS CORP (US) 2010-09-30 US claimed
EP-1984338-A2 PYRIDYLPHENYL COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES Synta Pharmaceuticals Corporation (US) 2008-10-29 EP claimed
US-20070254926-A1 Pyridylphenyl compounds for inflammation and immune-related uses SYNTA PHARMACEUTICALS CORP. 2007-11-01 US claimed
WO-2007089904-A2 PYRIDYLPHENYL COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES SYNTA PHARMACEUTICALS CORP. (US) 2007-08-09 WO claimed
US-10798940-B2 Penflufen polymer particles LANXESS DEUTSCHLAND GMBH (DE) 2020-10-13 US disclosed
US-10604685-B2 Aqueous polymer dispersions for composite film lamination BASF SE (DE) 2020-03-31 US disclosed
US-20180242588-A1 BIOCIDAL MIXTURES LANXESS DEUTSCHLAND GMBH (DE) 2018-08-30 US disclosed
US-20180235222-A1 PENFLUFEN POLYMER PARTICLES LANXESS DEUTSCHLAND GMBH (DE) 2018-08-23 US disclosed
EP-2676976-B2 Emulsion Polymers With Improved Wet Scrub Resistance Having One Or More Silicon Containing Compounds CELANESE SALES GERMANY GMBH (DE) 2018-07-11 EP disclosed
US-20180118985-A1 AQUEOUS POLYMER DISPERSIONS FOR COMPOSITE FILM LAMINATION BASF SE (DE) 2018-05-03 US disclosed
WO-2007089904-A2 PYRIDYLPHENYL COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES SYNTA PHARMACEUTICALS CORP. (US) 2007-08-09 WO disclosed
US-20060257673-A1 Laminates, their production and use CELANESE EMULSIONS GMBH (DE) 2006-11-16 US disclosed
US-20050124759-A1 Aqueous coating compositions method for the production thereof and their use for producing in particular thixotropic coating compositions CELANESE EMULSIONS GMBH (DE) 2005-06-09 US disclosed
US-6451899-B1 Aqueous formulations comprising at least two different polymers as aqueous dispersions BASF AKTIENGESELLSCHAFT (DE) 2002-09-17 US disclosed
US-5646325-A Process for the preparation of 3-acryloyloxypropylalkoxysilanes HUELS AKTIENGESELLSCHAFT (DE) 1997-07-08 US disclosed
US-4579809-A Positive image formation CIBA-GEIGY CORPORATION (US) 1986-04-01 US disclosed
EP-0053010-B1 ACIDIC ADHESIVE COMPOSITIONS AND IMAGE RECORDING PRODUCTS CONTAINING SAME EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1985-01-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070254926-A1 Pyridylphenyl compounds for inflammation and immune-related uses CCR1, CXCR3, NLRP1 IL2 77/4885ABL1 2986/4885RAF1 2343/4885
US-20140187586-A1 PYRIDYLPHENYL COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES CCR1, CXCR3, NLRP1 IL2 77/4885ABL1 2986/4885RAF1 2343/4885
US-20180242588-A1 BIOCIDAL MIXTURES PUF60, BTF3, AOC3 IL2 2369/4885ABL1 2404/4885RAF1 4668/4885
US-10798940-B2 Penflufen polymer particles FAP, PUF60, MATR3 IL2 1586/4885ABL1 2944/4885RAF1 4206/4885
US-20100249195-A1 PYRIDYLPHENYL COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES CCR1, CXCR3, NLRP1 IL2 77/4885ABL1 2986/4885RAF1 2343/4885
US-20180235222-A1 PENFLUFEN POLYMER PARTICLES FAP, PUF60, MATR3 IL2 1586/4885ABL1 2944/4885RAF1 4206/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.