Sugi Predict

Sugi Predict / Compounds / SCHEMBL4511075

SCHEMBL4511075

SCHEMBL4511075

COc1ccc(Cn2c(C)cc(OCc3ccccc3CNC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc(O)c(Cl)c3)cc2=O)cc1

nearest known ligand 0.51

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ MAPK14 Q16539 15/20 0.51
▸ MAPK11 Q15759 5/20 0.47
▸ FLT1 P17948 1/20 0.47
▸ MINK1 Q8N4C8 1/20 0.47
▸ MAPK12 P53778 7/20 0.46
▸ MAPK13 O15264 4/20 0.46
▸ SRC P12931 3/20 0.41
▸ HCK P08631 2/20 0.41
▸ PTK2B Q14289 2/20 0.41
▸ ITGA4 P13612 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4521147 0.93 MAPK14 (0.54) MAPK14MAPK11MAPK12MAPK13SRC
SCHEMBL4510580 0.92 MAPK14 (0.49) MAPK14MAPK11MAPK12MAPK13SRC
SCHEMBL4520778 0.90 MAPK14 (0.50) MAPK14MAPK11FLT1MINK1MAPK12
SCHEMBL4510645 0.90 MAPK11 (0.52) MAPK14MAPK11FLT1MINK1MAPK12
SCHEMBL13678552 0.87 MAPK14 (0.60) MAPK14MAPK11MAPK12MAPK13
SCHEMBL13678576 0.85 MAPK14 (0.49) MAPK14MAPK11FLT1MINK1MAPK12
SCHEMBL4505666 0.85 MAPK14 (0.51) MAPK14MAPK11FLT1MINK1MAPK12
SCHEMBL4519374 0.84 MAPK14 (0.48) MAPK14MAPK11FLT1MINK1MAPK12
SCHEMBL4501076 0.83 MAPK14 (0.49) MAPK14MAPK11FLT1MINK1MAPK12
SCHEMBL4520204 0.83 MAPK14 (0.49) MAPK14MAPK11FLT1MINK1MAPK12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090270350-A1 Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives PFIZER INC. 2009-10-29 — — US claimed
EP-1987022-A1 PYRIDINONE PYRAZOLE UREA AND PYRIMIDINONE PYRAZOLE UREA DERIVATIVES Pfizer Products Inc. (US) 2008-11-05 — — EP claimed
WO-2007091176-A1 PYRIDINONE PYRAZOLE UREA AND PYRIMIDINONE PYRAZOLE UREA DERIVATIVES PFIZER PRODUCTS INC. (US) 2007-08-16 — — WO claimed
US-20090270350-A1 Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives PFIZER INC. 2009-10-29 — — US disclosed
US-20090270350-A1 Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives PFIZER INC. 2009-10-29 — — US disclosed
US-20090270350-A1 Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives PFIZER INC. 2009-10-29 — — US disclosed
EP-1987022-A1 PYRIDINONE PYRAZOLE UREA AND PYRIMIDINONE PYRAZOLE UREA DERIVATIVES Pfizer Products Inc. (US) 2008-11-05 — — EP disclosed
WO-2007091176-A1 PYRIDINONE PYRAZOLE UREA AND PYRIMIDINONE PYRAZOLE UREA DERIVATIVES PFIZER PRODUCTS INC. (US) 2007-08-16 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090270350-A1 Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives PDXK, UMPS, CDK2 MAPK14 117/4885MAPK11 404/4885FLT1 1173/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.