Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 9/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 8/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 0.44 |
| ▸ | BCHE | P06276 | 5/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.40 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL448842 | 0.90 | HDAC3 (0.43) | HDAC4HDAC1HDAC6HDAC3HDAC7 | |
| SCHEMBL451613 | 0.89 | HTT (0.49) | BCHEKCNA5CYSLTR1S1PR1S1PR3 | |
| SCHEMBL447970 | 0.88 | BCHE (0.52) | BCHEKCNA5CYSLTR1S1PR1S1PR3 | |
| SCHEMBL451860 | 0.85 | TSHR (0.49) | BCHEPPARGPPARAKCNA5CYSLTR1 | |
| SCHEMBL451372 | 0.84 | HTT (0.50) | BCHEKCNA5CYSLTR1S1PR1S1PR3 | |
| SCHEMBL448483 | 0.84 | LTA4H (0.53) | BCHEPPARGPPARACYSLTR1S1PR1 | |
| SCHEMBL447899 | 0.84 | BCHE (0.46) | BCHEPPARGPPARAACHEKCNA5 | |
| SCHEMBL452358 | 0.84 | TDP1 (0.49) | BCHE | |
| SCHEMBL450152 | 0.84 | ALDH1A1 (0.39) | HDAC4HDAC1HDAC6HDAC3HDAC7 | |
| SCHEMBL449223 | 0.83 | BCHE (0.44) | BCHEPPARGPPARAKCNA5CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8653305-B2 | Compound having S1P receptor binding potency and use thereof | ONO PHARMACEUTICAL CO., LTD. (JP) | 2014-02-18 | — | — | US | claimed |
| US-8653305-B2 | Compound having S1P receptor binding potency and use thereof | ONO PHARMACEUTICAL CO., LTD. (JP) | 2014-02-18 | — | — | US | disclosed |
| US-20120064060-A1 | COMPOUND HAVING S1P RECEPTOR BINDING POTENCY AND USE THEREOF | ONO PHARMACEUTICAL CO., LTD. (JP) | 2012-03-15 | — | — | US | disclosed |
| US-8039674-B2 | Amino-substituted cyclic compound for EDG-1(endothelial differentiation gene) and/or EDG-6-mediated diseases; transplant rejection, autoimmune diseases, allergies, asthma, multiple organ failure, ischemia, reperfusion injury, lung or liver fibrosis; antitumor agents | ONO PHARMACEUTICAL CO., LTD. (JP) | 2011-10-18 | — | — | US | disclosed |
| US-20080207584-A1 | Compound Having S1P Receptor Binding Potency and Use Thereof | ONO PHARMACEUTICAL CO., LTD. (JP) | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120064060-A1 | COMPOUND HAVING S1P RECEPTOR BINDING POTENCY AND USE THEREOF | S1PR1, S1PR3, EDNRA | HDAC4 2533/4885HDAC1 625/4885HDAC6 3649/4885 |
| US-20080207584-A1 | Compound Having S1P Receptor Binding Potency and Use Thereof | S1PR1, EDNRA, S1PR3 | HDAC4 2649/4885HDAC1 653/4885HDAC6 3573/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.