Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.44 |
| ▸ | NNMT | P40261 | 1/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | APOBEC3A | P31941 | 3/20 | 0.54 |
| ▸ | APOBEC3G | Q9HC16 | 3/20 | 0.54 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3841152 | 0.98 | NNMT (0.61) | NNMTUSP2APOBEC3AAPOBEC3GPABPC1 | |
| Iodide SCHEMBL8724842 | 0.87 | NNMT (0.61) | NNMTUSP2APOBEC3AAPOBEC3GPABPC1 | |
| SCHEMBL8724844 | 0.85 | NNMT (0.63) | NNMTUSP2APOBEC3AAPOBEC3GPABPC1 | |
| SCHEMBL6514078 | 0.82 | TCF4 (0.49) | NNMTUSP2APOBEC3AAPOBEC3GPABPC1 | |
| SCHEMBL10307402 | 0.79 | GLA (0.58) | NNMTUSP2APOBEC3AAPOBEC3GTSHR | |
| SCHEMBL12039197 | 0.78 | TSHR (0.53) | TSHRALDH1A1RECQLSMN1; SMN2ABL1 | |
| SCHEMBL5237493 | 0.78 | TSHR (0.53) | NNMTTSHRALDH1A1RECQLABL1 | |
| SCHEMBL2818943 | 0.78 | ABL1 (0.67) | TSHRALDH1A1RECQLABL1RIN1 | |
| SCHEMBL14067665 | 0.77 | NNMT (0.54) | NNMTUSP2APOBEC3AAPOBEC3GPABPC1 | |
| Iodide SCHEMBL21082042 | 0.77 | NNMT (0.54) | NNMTUSP2APOBEC3AAPOBEC3GPABPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090258883-A1 | 1H-Indole-Pyridinecarboxamide and 1H-Indole-Piperidinecarboxamide Compounds | LES LABORATOIRES SERVIER (FR) | 2009-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258883-A1 | 1H-Indole-Pyridinecarboxamide and 1H-Indole-Piperidinecarboxamide Compounds | IDO1, AHR, IDO2 | ACHE 1681/4885NNMT 1166/4885USP2 3146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.