SCHEMBL451291

SCHEMBL451291

C1=CNc2ccccc2[N]1

nearest known ligand 0.32

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
GRK6 P43250 1/20 0.32
GAA P10253 1/20 0.32
MAPT P10636 1/20 0.32
PLAU P00749 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1096642 0.70 GSK3B (0.38) GAAMAPT
SCHEMBL1096641 0.70 MAOA (0.36) MAPTPLAU
SCHEMBL9958738 0.68 GRK6 (0.34) GRK6
SCHEMBL2903859 0.68 GRK6 (0.34) GRK6
SCHEMBL330550 0.68 GRK6 (0.34) GRK6
SCHEMBL9958734 0.68 GRK6 (0.34) GRK6
SCHEMBL5793142 0.67 PLAU (0.31) PLAU
Hydrochloric Acid SCHEMBL7477355 0.67 GRK6 (0.33) GRK6MAPT
SCHEMBL27344588 0.67 GRK6 (0.33) GRK6
SCHEMBL4471762 0.67

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 104 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117836296-A Pyrazolopyridone compounds 百济神州有限公司 2024-04-05 CN claimed
WO-2023125681-A1 HETEROCYCLIC COMPOUNDS BEIGENE, LTD. (KY) 2023-07-06 WO claimed
EP-4028400-A1 SUBSTITUTED IMIDAZOQUINOXALINE COMPOUNDS AND USES THEREOF Impact Therapeutics (Shanghai), Inc (CN) 2022-07-20 EP claimed
WO-2021078217-A1 TETRACENE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF 中国科学院化学研究所 2021-04-29 WO claimed
CN-112694388-A Naphthacene derivative and preparation method and application thereof 中国科学院化学研究所 2021-04-23 CN claimed
WO-2021047646-A1 SUBSTITUTED IMIDAZOQUINOXALINE COMPOUNDS AND USES THEREOF IMPACT THERAPEUTICS, INC (CN) 2021-03-18 WO claimed
EP-1926712-B1 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS LILLY CO ELI (US) 2009-07-29 EP claimed
CN-87101864-A Pyrazolo [3,4-d] pyrimidine derivatives and production and purposes 1987-11-18 CN claimed
EP-4380936-A1 PYRAZOLOPYRIDINONE COMPOUNDS BeiGene, Ltd. (KY) 2024-06-12 EP disclosed
CN-117836296-A Pyrazolopyridone compounds 百济神州有限公司 2024-04-05 CN disclosed
CN-112673009-B Substituted triazoloquinoxaline derivatives 格吕伦塔尔有限公司 2023-09-19 CN disclosed
WO-2023125681-A1 HETEROCYCLIC COMPOUNDS BEIGENE, LTD. (KY) 2023-07-06 WO disclosed
CN-114085220-B Substituted morpholine-4-carboxylic acid ester derivatives, compositions and pharmaceutical uses thereof 上海海雁医药科技有限公司 2023-06-16 CN disclosed
WO-2023011456-A1 PYRAZOLOPYRIDINONE COMPOUNDS BEIGENE, LTD. (KY) 2023-02-09 WO disclosed
EP-1348701-A1 (2,4-disubstituted-thiazol-5-yl) amine compounds as PDE7 inhibitors Warner-Lambert Company LLC (US) 2003-10-01 EP disclosed
EP-1348433-A1 Thiazol-2-yl-imine compounds as PDE-7 inhibitors Warner-Lambert Company LLC (US) 2003-10-01 EP disclosed
CN-1364161-A N-substituted perhydrodiazines BASF AG (DE) 2002-08-14 CN disclosed
WO-2001092236-A1 4-ALKYL HALIDE TRIAZINE COMPOUNDS USED AS HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 2001-12-06 WO disclosed
WO-2001090085-A2 6-METHYL-4-TRIHALOMETHYLTRIAZINE COMPOUNDS BASF AKTIENGESELLSCHAFT (DE) 2001-11-29 WO disclosed
CN-87101864-A Pyrazolo [3,4-d] pyrimidine derivatives and production and purposes 1987-11-18 CN disclosed