Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.36 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.34 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.34 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4522211 | 0.91 | TDP2 (0.39) | TDP2CNR1CNR2AKR1C3AKR1C2 | |
| SCHEMBL4524091 | 0.88 | NPC1 (0.40) | TDP2AKR1C3AKR1C2PDGFRBPDGFRA | |
| SCHEMBL4521786 | 0.88 | TDP2 (0.40) | TDP2AKR1C3AKR1C2PDGFRBPDGFRA | |
| SCHEMBL4526682 | 0.88 | TDP2 (0.40) | TDP2AKR1C3AKR1C2PDGFRBPDGFRA | |
| SCHEMBL4530670 | 0.87 | NPC1 (0.39) | TDP2AKR1C3AKR1C2PDGFRBPDGFRA | |
| SCHEMBL4521931 | 0.87 | NPC1 (0.41) | TDP2AKR1C3AKR1C2PDGFRBPDGFRA | |
| SCHEMBL4523901 | 0.86 | PDGFRB (0.40) | TDP2AKR1C3AKR1C2PDGFRBPDGFRA | |
| SCHEMBL4527844 | 0.83 | TDP2 (0.41) | TDP2CNR1CNR2AKR1C3AKR1C2 | |
| SCHEMBL4530842 | 0.81 | AKR1C3 (0.42) | TDP2CNR1CNR2AKR1C3AKR1C2 | |
| SCHEMBL4512390 | 0.80 | BIRC5 (0.44) | TDP2AKR1C3AKR1C2PDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1736471-B1 | 3-(DIHYDRO(TETRAHYDRO)ISOQUINOLIN-1-YL)QUINOLINES | MITSUI CHEMICALS AGRO INC (JP) | 2014-01-08 | — | — | EP | disclosed |
| US-7632783-B2 | fungicides, pesticides for protecting rice crop, tomatoes, cucumbers and green beans; 3-(5-fluoro-3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)quinoline | MITSUI CHEMICALS AGRO, INC. (JP) | 2009-12-15 | — | — | US | disclosed |
| US-20080275242-A1 | 3-(Dihydro(Tetrahydro)Isoquinolin-1-Yl)Quinoline Compound | MITSUI CHEMICALS CROP & LIFE SOLUTIONS, INC. (JP) | 2008-11-06 | — | — | US | disclosed |
| EP-1736471-A1 | 3-(DIHYDRO(TETRAHYDRO)ISOQUINOLIN-1-YL)QUINOLINES | Sankyo Agro Company, Limited (JP) | 2006-12-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275242-A1 | 3-(Dihydro(Tetrahydro)Isoquinolin-1-Yl)Quinoline Compound | QTRT1, RABL3, RECQL | TDP2 1584/4885CNR1 1548/4885CNR2 3088/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.