Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 5/20 | 0.41 |
| ▸ | CA1 | P00915 | 5/20 | 0.41 |
| ▸ | CA9 | Q16790 | 5/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22700982 | 0.85 | ALDH1A1 (0.48) | HPGDALDH1A1GAAMAPTMEN1 | |
| SCHEMBL4509661 | 0.83 | ALDH1A1 (0.47) | HPGDALDH1A1GAAMAPTMEN1 | |
| SCHEMBL4516025 | 0.83 | ALDH1A1 (0.47) | HPGDALDH1A1GAAMAPTMEN1 | |
| SCHEMBL27762926 | 0.80 | ALDH1A1 (0.53) | HPGDALDH1A1GAAMAPTMEN1 | |
| SCHEMBL5049281 | 0.80 | MAPT (0.43) | HPGDALDH1A1GAAMAPTMEN1 | |
| SCHEMBL10650052 | 0.79 | MCL1 (0.54) | HPGDALDH1A1GAAMAPTMEN1 | |
| SCHEMBL10606335 | 0.79 | NQO1 (0.48) | HPGDALDH1A1GAAMAPTMEN1 | |
| SCHEMBL7109956 | 0.78 | MEN1 (0.44) | HPGDALDH1A1GAAMAPTMEN1 | |
| SCHEMBL4778778 | 0.77 | ALDH1A1 (0.50) | HPGDALDH1A1GAAMAPTMEN1 | |
| SCHEMBL10604603 | 0.76 | ACACB (0.43) | HPGDALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090264485-A1 | Pyrazole Derivatives, Their Manufacture and Their Use as Pharmaceutical Agents | F. HOFFMANN-LA ROCHE AG (CH) | 2009-10-22 | — | — | US | disclosed |
| US-20090264485-A1 | Pyrazole Derivatives, Their Manufacture and Their Use as Pharmaceutical Agents | F. HOFFMANN-LA ROCHE AG (CH) | 2009-10-22 | — | — | US | disclosed |
| US-20090264485-A1 | Pyrazole Derivatives, Their Manufacture and Their Use as Pharmaceutical Agents | F. HOFFMANN-LA ROCHE AG (CH) | 2009-10-22 | — | — | US | disclosed |
| CN-101208335-A | Pyrazole derivatives, their manufacture and their use as pharmaceutical agents | HOFFMANN LA ROCHE (CH) | 2008-06-25 | — | — | CN | disclosed |
| EP-1915370-A1 | PYRAZOLE DERIVATIVES, THEIR MANUFACTURE AND THEIR USE AS PHARMACEUTICAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-04-30 | — | — | EP | disclosed |
| WO-2007017222-A1 | PYRAZOLE DERIVATIVES, THEIR MANUFACTURE AND THEIR USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-15 | — | — | WO | disclosed |
| WO-2007017222-A1 | PYRAZOLE DERIVATIVES, THEIR MANUFACTURE AND THEIR USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264485-A1 | Pyrazole Derivatives, Their Manufacture and Their Use as Pharmaceutical Agents | CYP3A5, CYP3A43, CYP3A7 | HPGD 138/4885ALDH1A1 128/4885GAA 1984/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.