Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | GRM5 | P41594 | 5/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29849858 | 1.00 | NPC1 (0.62) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL29501764 | 0.89 | NPC1 (0.50) | NPC1RAB9AMAPTGRM5KDM4E | |
| SCHEMBL28413062 | 0.89 | NPC1 (0.50) | NPC1RAB9AMAPTGRM5KDM4E | |
| SCHEMBL29501850 | 0.88 | RAB9A (0.47) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL28403065 | 0.88 | RAB9A (0.47) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL29501822 | 0.84 | MAPT (0.57) | MAPTGRM5IDO1L3MBTL1 | |
| SCHEMBL28402729 | 0.84 | MAPT (0.57) | MAPTGRM5IDO1L3MBTL1 | |
| SCHEMBL3872115 | 0.81 | MEN1 (0.55) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL3245214 | 0.81 | HAO1 (0.47) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL31532396 | 0.81 | ALDH1A1 (0.60) | NPC1RAB9AMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113235116-B | Electrochemical synthesis method of bromopyridine derivative | 齐鲁工业大学 | 2022-08-16 | — | — | CN | disclosed |
| CN-113235116-A | Electrochemical synthesis method of bromopyridine derivative | 齐鲁工业大学 | 2021-08-10 | — | — | CN | disclosed |
| US-20090286827-A1 | NOVEL BI-ARYL AMINES | NOVARTIS AG (CH) | 2009-11-19 | — | — | US | disclosed |
| CN-101460478-A | Novel bi-aryl amines | NOVARTIS AG (CH) | 2009-06-17 | — | — | CN | disclosed |
| EP-2004624-A1 | NOVEL BI-ARYL AMINES | Novartis AG (CH) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007113276-A1 | NOVEL BI-ARYL AMINES | NOVARTIS AG (CH) | 2007-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286827-A1 | NOVEL BI-ARYL AMINES | NAT1, MAOB, CYP2B6 | NPC1 564/4885RAB9A 988/4885MEN1 2322/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.