Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | PFKFB3 | Q16875 | 2/20 | 0.32 |
| ▸ | PFKFB2 | O60825 | 1/20 | 0.32 |
| ▸ | PFKFB1 | P16118 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 3/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4516372 | 1.00 | P2RX3 (0.34) | P2RX3CTSLPFKFB3PFKFB2PFKFB1 | |
| SCHEMBL4514235 | 0.91 | CTSL (0.36) | P2RX3CTSLIDH1 | |
| SCHEMBL4514233 | 0.91 | CTSL (0.36) | P2RX3CTSLIDH1 | |
| SCHEMBL13763254 | 0.90 | CTSL (0.34) | P2RX3CTSLIDH1 | |
| SCHEMBL4518034 | 0.90 | HTR1D (0.35) | P2RX3CTSLIDH1KDM4C | |
| SCHEMBL4518032 | 0.90 | HTR1D (0.35) | P2RX3CTSLIDH1KDM4C | |
| SCHEMBL13854964 | 0.88 | P2RX3 (0.33) | P2RX3PFKFB3PFKFB2PFKFB1 | |
| SCHEMBL4506959 | 0.85 | NPC1 (0.35) | IDH1KDM4C | |
| SCHEMBL5346339 | 0.85 | NPC1 (0.35) | IDH1KDM4C | |
| SCHEMBL13763493 | 0.83 | CTSL (0.35) | P2RX3CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090203744-A1 | NOVEL PYRIDINE DERIVATIVES | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2009-08-13 | — | — | US | claimed |
| WO-2007029062-A2 | NOVEL PYRIDINE DERIVATIVES | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2007-03-15 | — | — | WO | claimed |
| US-20090203744-A1 | NOVEL PYRIDINE DERIVATIVES | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2009-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203744-A1 | NOVEL PYRIDINE DERIVATIVES | CYP3A4, CYP4B1, CYP3A5 | P2RX3 161/4885CTSL 4355/4885PFKFB3 728/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.