Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4505874 | 0.91 | MAPK14 (0.44) | MAPK14BRAF | |
| SCHEMBL4498644 | 0.90 | MAPK14 (0.48) | MAPK14BRAF | |
| SCHEMBL4510133 | 0.89 | MAPK14 (0.49) | MAPK14BRAF | |
| SCHEMBL4503033 | 0.89 | MAPK14 (0.53) | MAPK14BRAF | |
| SCHEMBL4508986 | 0.89 | MAPK14 (0.52) | MAPK14BRAF | |
| SCHEMBL4509558 | 0.87 | MAPK14 (0.46) | MAPK14BRAF | |
| SCHEMBL4497782 | 0.84 | MAPK14 (0.46) | MAPK14BRAF | |
| SCHEMBL4513966 | 0.83 | MAPK14 (0.49) | MAPK14BRAF | |
| SCHEMBL4508315 | 0.82 | MAPK14 (0.49) | MAPK14BRAF | |
| SCHEMBL4506025 | 0.81 | MAPK14 (0.54) | MAPK14BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090270350-A1 | Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives | PFIZER INC. | 2009-10-29 | — | — | US | claimed |
| EP-1987022-A1 | PYRIDINONE PYRAZOLE UREA AND PYRIMIDINONE PYRAZOLE UREA DERIVATIVES | Pfizer Products Inc. (US) | 2008-11-05 | — | — | EP | claimed |
| WO-2007091176-A1 | PYRIDINONE PYRAZOLE UREA AND PYRIMIDINONE PYRAZOLE UREA DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2007-08-16 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270350-A1 | Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives | PDXK, UMPS, CDK2 | MAPK14 117/4885BRAF 635/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.