Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4521487 | 0.84 | HDAC6 (0.31) | HDAC6KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL4529715 | 0.83 | RORC (0.33) | KDM4ERAB9A | |
| SCHEMBL4507997 | 0.78 | KDM2B (0.34) | KDM2BHDAC6ALDH1A1 | |
| SCHEMBL4527465 | 0.76 | KDM2B (0.37) | KDM2BHDAC6 | |
| SCHEMBL4430327 | 0.74 | KDM4E (0.42) | HDAC6KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL4520652 | 0.73 | KDM1A (0.45) | KDM2BHDAC6 | |
| SCHEMBL4431716 | 0.73 | HDAC6 (0.35) | HDAC6KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL4426746 | 0.73 | MEN1 (0.48) | HDAC6KDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL4529322 | 0.70 | HSD11B1 (0.36) | KDM4ERAB9A | |
| SCHEMBL4437343 | 0.69 | TSHR (0.38) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090099158-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-04-16 | — | — | US | claimed |
| US-20090099158-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099158-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | HRH3, HRH4, HRH1 | KDM2B 1123/4885HDAC6 848/4885KDM4E 1117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.