Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 17/20 | 0.75 |
| ▸ | BRD4 | O60885 | 12/20 | 0.75 |
| ▸ | TAF1 | P21675 | 2/20 | 0.75 |
| ▸ | BRDT | Q58F21 | 6/20 | 0.75 |
| ▸ | PLK3 | Q9H4B4 | 5/20 | 0.75 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.75 |
| ▸ | CLK2 | P49760 | 3/20 | 0.75 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.75 |
| ▸ | CAMK2G | Q13555 | 3/20 | 0.75 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.75 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.75 |
| ▸ | CSNK1G1 | Q9HCP0 | 3/20 | 0.75 |
| ▸ | CSNK1G3 | Q9Y6M4 | 3/20 | 0.75 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.75 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.75 |
| ▸ | EGFR | P00533 | 2/20 | 0.75 |
| ▸ | FES | P07332 | 2/20 | 0.75 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.75 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.75 |
| ▸ | NEK2 | P51955 | 2/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4531747 | 0.94 | PLK1 (0.77) | PLK1BRD4TAF1BRDTPLK3 | |
| SCHEMBL13611484 | 0.89 | PLK1 (0.81) | PLK1BRD4TAF1BRDTPLK3 | |
| SCHEMBL4302288 | 0.89 | PLK1 (0.81) | PLK1BRD4TAF1BRDTPLK3 | |
| SCHEMBL4506644 | 0.89 | BRD4 (0.77) | PLK1BRD4TAF1BRDTPLK3 | |
| SCHEMBL4514965 | 0.89 | PLK1 (0.61) | PLK1BRD4TAF1BRDTPLK3 | |
| SCHEMBL4511601 | 0.89 | PLK1 (0.78) | PLK1BRD4TAF1BRDTPLK3 | |
| SCHEMBL22459208 | 0.88 | PLK1 (0.71) | PLK1BRD4TAF1BRDTPLK3 | |
| SCHEMBL4531390 | 0.87 | PLK1 (0.59) | PLK1BRD4TAF1BRDTPLK3 | |
| SCHEMBL18261939 | 0.86 | PLK1 (1.00) | PLK1BRD4TAF1BRDTPLK3 | |
| SCHEMBL16984430 | 0.86 | PLK1 (1.00) | PLK1BRD4TAF1BRDTPLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090312336-A1 | DIHYDROPTERIDINE COMPOUNDS AS ANTI PROLIFERATIVE AGENTS | ASTRAZENECA AB (SE) | 2009-12-17 | — | — | US | disclosed |
| US-20090312336-A1 | DIHYDROPTERIDINE COMPOUNDS AS ANTI PROLIFERATIVE AGENTS | ASTRAZENECA AB (SE) | 2009-12-17 | — | — | US | disclosed |
| US-20090312336-A1 | DIHYDROPTERIDINE COMPOUNDS AS ANTI PROLIFERATIVE AGENTS | ASTRAZENECA AB (SE) | 2009-12-17 | — | — | US | disclosed |
| WO-2007135374-A1 | DIHYDROPTERIDINE COMPOUNDS AS ANTI PROLIFERATIVE AGENTS | ASTRAZENECA AB (SE) | 2007-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312336-A1 | DIHYDROPTERIDINE COMPOUNDS AS ANTI PROLIFERATIVE AGENTS | QDPR, PLK2, PFKP | PLK1 235/4885BRD4 4692/4885TAF1 4668/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.