Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.38 |
| ▸ | HCK | P08631 | 2/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4520888 | 0.96 | MAPK14 (0.44) | MAPK14MAPK12MAPK11MAPK13FLT1 | |
| SCHEMBL4512586 | 0.95 | MAPK14 (0.46) | MAPK14MAPK12MAPK11MAPK13HCK | |
| SCHEMBL4522868 | 0.95 | MAPK14 (0.43) | MAPK14MAPK12MAPK11MAPK13 | |
| SCHEMBL4511381 | 0.94 | MAPK14 (0.48) | MAPK14MAPK12MAPK11MAPK13FLT1 | |
| SCHEMBL4512853 | 0.92 | MAPK14 (0.49) | MAPK14MAPK12MAPK11MAPK13FLT1 | |
| SCHEMBL4507328 | 0.92 | MAPK14 (0.49) | MAPK14MAPK12MAPK11MAPK13FLT1 | |
| SCHEMBL4505994 | 0.90 | MAPK14 (0.46) | MAPK14MAPK12MAPK11MAPK13FLT1 | |
| SCHEMBL4508440 | 0.89 | MAPK14 (0.45) | MAPK14MAPK12MAPK11MAPK13FLT1 | |
| SCHEMBL4513541 | 0.89 | MAPK14 (0.42) | MAPK14MAPK12MAPK11MAPK13 | |
| SCHEMBL4498136 | 0.88 | MAPK14 (0.43) | MAPK14MAPK12MAPK11MAPK13FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090270350-A1 | Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives | PFIZER INC. | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270350-A1 | Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives | PDXK, UMPS, CDK2 | MAPK14 117/4885MAPK12 178/4885MAPK11 404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.