Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 12/20 | 0.57 |
| ▸ | NPY5R | Q15761 | 7/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4518318 | 1.00 | HSD11B1 (0.57) | HSD11B1NPY5RCYP2D6OPRD1KCNH2 | |
| SCHEMBL4511309 | 0.94 | HSD11B1 (0.57) | HSD11B1NPY5RCYP2D6OPRD1KCNH2 | |
| SCHEMBL4511306 | 0.94 | HSD11B1 (0.57) | HSD11B1NPY5RCYP2D6OPRD1KCNH2 | |
| SCHEMBL4507185 | 0.91 | HSD11B1 (0.68) | HSD11B1NPY5RCYP2D6 | |
| SCHEMBL4507187 | 0.91 | HSD11B1 (0.68) | HSD11B1NPY5RCYP2D6 | |
| SCHEMBL4515880 | 0.88 | HSD11B1 (0.58) | HSD11B1NPY5RCYP2D6 | |
| SCHEMBL4515873 | 0.88 | HSD11B1 (0.58) | HSD11B1NPY5RCYP2D6 | |
| SCHEMBL4516922 | 0.87 | HSD11B1 (0.69) | HSD11B1NPY5RCYP2D6 | |
| SCHEMBL4516924 | 0.87 | HSD11B1 (0.69) | HSD11B1NPY5RCYP2D6 | |
| SCHEMBL4513841 | 0.85 | HSD11B1 (0.68) | HSD11B1NPY5RCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090298808-A1 | INHIBITORS OF 11-BETA HYDROXYL STEROID DEHYDROGENASE TYPE I AND METHODS OF USING THE SAME | INCYTE CORPORATION, A DELAWARE CORPORATION | 2009-12-03 | — | — | US | claimed |
| US-20060122210-A1 | Inhibitors of 11-beta hydroxyl steroid dehydrogenase type I and methods of using the same | INCYTE CORPORATION | 2006-06-08 | — | — | US | claimed |
| US-20090298808-A1 | INHIBITORS OF 11-BETA HYDROXYL STEROID DEHYDROGENASE TYPE I AND METHODS OF USING THE SAME | INCYTE CORPORATION, A DELAWARE CORPORATION | 2009-12-03 | — | — | US | disclosed |
| US-20060122210-A1 | Inhibitors of 11-beta hydroxyl steroid dehydrogenase type I and methods of using the same | INCYTE CORPORATION | 2006-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122210-A1 | Inhibitors of 11-beta hydroxyl steroid dehydrogenase type I and methods of using the same | HSD11B1, HSD11B2, HSD17B1 | HSD11B1 1/4885NPY5R 1599/4885CYP2D6 253/4885 |
| US-20090298808-A1 | INHIBITORS OF 11-BETA HYDROXYL STEROID DEHYDROGENASE TYPE I AND METHODS OF USING THE SAME | HSD11B1, HSD11B2, HSD17B1 | HSD11B1 1/4885NPY5R 1599/4885CYP2D6 253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.