SCHEMBL4518637

SCHEMBL4518637

CCOC(=O)CCCOc1cccc2cc(/C(Cl)=C/C=C/C(=O)N3CCOCC3)oc12

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
F2RL3 Q96RI0 2/20 0.45
RXFP1 Q9HBX9 1/20 0.39
RAB9A P51151 4/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
KDM4E B2RXH2 5/20 0.37
HPGD P15428 3/20 0.37
NPC1 O15118 2/20 0.37
GLA P06280 1/20 0.37
MAPK1 P28482 1/20 0.37
HRH3 Q9Y5N1 1/20 0.37
KMT2A Q03164 3/20 0.37
MEN1 O00255 2/20 0.37
APP P05067 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
TRPV1 Q8NER1 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
ALDH1A1 P00352 1/20 0.35
MAPT P10636 1/20 0.35
PPARG P37231 1/20 0.35
HSD17B10 Q99714 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4514619 0.89 RXFP1 (0.40) RXFP1RAB9AKDM4EHPGDNPC1
SCHEMBL4514615 0.89 RXFP1 (0.40) RXFP1RAB9AKDM4EHPGDNPC1
SCHEMBL4514613 0.89 RXFP1 (0.40) RXFP1RAB9AKDM4EHPGDNPC1
SCHEMBL13600826 0.85 F2RL3 (0.49) F2RL3RXFP1RAB9AL3MBTL1KDM4E
SCHEMBL4505830 0.83 RXFP1 (0.52) RXFP1RAB9AL3MBTL1KDM4EHPGD
SCHEMBL4505825 0.83 RXFP1 (0.52) RXFP1RAB9AL3MBTL1KDM4EHPGD
SCHEMBL4505833 0.83 RXFP1 (0.52) RXFP1RAB9AL3MBTL1KDM4EHPGD
SCHEMBL4518627 0.82 F2RL3 (0.51) F2RL3RAB9ANPC1HRH3KMT2A
SCHEMBL4518630 0.82 F2RL3 (0.51) F2RL3RAB9ANPC1HRH3KMT2A
SCHEMBL13600952 0.82 F2RL3 (0.51) F2RL3RAB9ANPC1HRH3KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7638540-B2 Benzofuran compound and medicinal composition containing the same THE NEW INDUSTRY RESEARCH ORGANIZATION (JP) 2009-12-29 US disclosed
US-7638540-B2 Benzofuran compound and medicinal composition containing the same THE NEW INDUSTRY RESEARCH ORGANIZATION (JP) 2009-12-29 US disclosed
US-7638540-B2 Benzofuran compound and medicinal composition containing the same THE NEW INDUSTRY RESEARCH ORGANIZATION (JP) 2009-12-29 US disclosed
US-20060194851-A1 Benzofuran compound and medicinal composition containing the same NEW INDUSTRY RESEARCH ORGANIZATION, THE (JP) 2006-08-31 US disclosed
EP-1627873-A1 BENZOFURAN COMPOUND AND MEDICINAL COMPOSITION CONTAINING THE SAME The New Industry Research Organization (JP) 2006-02-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060194851-A1 Benzofuran compound and medicinal composition containing the same LTB4R2, LTC4S, LTB4R F2RL3 364/4885RXFP1 2240/4885RAB9A 4698/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.