Sugi Predict

Sugi Predict / Compounds / SCHEMBL4518778

SCHEMBL4518778

SCHEMBL4518778

Cc1cccc(C)c1OCC(C)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 P04150 1/20 0.57
▸ FFAR4 Q5NUL3 2/20 0.48
▸ SCN8A Q9UQD0 2/20 0.46
▸ ALDH1A1 P00352 2/20 0.41
▸ TSHR P16473 2/20 0.41
▸ BCHE P06276 1/20 0.41
▸ ACHE P22303 1/20 0.41
▸ POLB P06746 1/20 0.40
▸ MMP2 P08253 2/20 0.40
▸ MMP9 P14780 2/20 0.40
▸ MMP14 P50281 2/20 0.40
▸ ADAM17 P78536 2/20 0.40
▸ SCN4A P35499 3/20 0.40
▸ LMNA P02545 2/20 0.40
▸ SCN1A P35498 2/20 0.40
▸ SCN5A Q14524 2/20 0.40
▸ SCN9A Q15858 2/20 0.40
▸ CYP1A2 P05177 1/20 0.40
▸ CYP3A4 P08684 1/20 0.40
▸ CYP2D6 P10635 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4516008 0.86 NR3C1 (0.59) NR3C1SCN8ATSHRPOLBMMP2
SCHEMBL4506870 0.85 NR3C1 (0.62) NR3C1FFAR4ALDH1A1POLBMMP2
SCHEMBL4516532 0.84 NR3C1 (0.57) NR3C1FFAR4ALDH1A1TSHRPOLB
SCHEMBL4509097 0.83 NR3C1 (0.59) NR3C1ALDH1A1POLBMMP2MMP9
SCHEMBL4511681 0.82 NR3C1 (0.58) NR3C1ALDH1A1TSHRPOLBMMP2
SCHEMBL4518136 0.82 NR3C1 (0.64) NR3C1SCN8AALDH1A1TSHRSCN4A
SCHEMBL4515277 0.82 NR3C1 (0.63) NR3C1SCN8AALDH1A1TSHRMMP2
SCHEMBL13889013 0.81 NR3C1 (0.59) NR3C1SCN8ATSHRMMP2MMP9
SCHEMBL13889015 0.81 NR3C1 (0.62) NR3C1ALDH1A1MMP2MMP9SCN4A
SCHEMBL4503992 0.79 NR3C1 (0.57) NR3C1SCN8AALDH1A1TSHRSCN4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090093485-A1 Novel Sulphonamide Derivatives as Glucocorticoid Receptor Modulators for the Treatment of Inflammatory Diseases ASTRAZENECA AB (SE) 2009-04-09 — — US disclosed
US-20090093485-A1 Novel Sulphonamide Derivatives as Glucocorticoid Receptor Modulators for the Treatment of Inflammatory Diseases ASTRAZENECA AB (SE) 2009-04-09 — — US disclosed
US-20090093485-A1 Novel Sulphonamide Derivatives as Glucocorticoid Receptor Modulators for the Treatment of Inflammatory Diseases ASTRAZENECA AB (SE) 2009-04-09 — — US disclosed
EP-1807391-A1 NOVEL SULPHONAMIDE DERIVATIVES AS GLUCOCORTICOID RECEPTOR MODULATORS FOR THE TREATMENT OF INFLAMMATORY DISEASES AstraZeneca AB (SE) 2007-07-18 — — EP disclosed
WO-2006046916-A1 NOVEL SULPHONAMIDE DERIVATIVES AS GLUCOCORTICOID RECEPTOR MODULATORS FOR THE TREATMENT OF INFLAMMATORY DISEASES ASTRAZENECA AB (SE) 2006-05-04 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090093485-A1 Novel Sulphonamide Derivatives as Glucocorticoid Receptor Modulators for the Treatment of Inflammatory Diseases NR3C1, NR3C2, NR5A1 NR3C1 1/4885FFAR4 230/4885SCN8A 575/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.