Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 16/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 15/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 14/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 8/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.59 |
| ▸ | USP2 | O75604 | 7/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 11/20 | 0.55 |
| ▸ | TSHR | P16473 | 7/20 | 0.55 |
| ▸ | LMNA | P02545 | 6/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 7/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4511273 | 0.86 | CYP1A2 (0.78) | CYP1A2CYP2D6CYP3A4ALOX15HSD17B10 | |
| SCHEMBL4520338 | 0.83 | ALK (0.53) | CYP1A2CYP2D6CYP3A4HSD17B10ALDH1A1 | |
| SCHEMBL4519837 | 0.77 | CHEK1 (0.57) | CYP1A2CYP2D6CYP3A4ALOX15HSD17B10 | |
| SCHEMBL3908964 | 0.75 | CYP1A2 (0.67) | CYP1A2CYP2D6CYP3A4ALOX15HSD17B10 | |
| SCHEMBL4516779 | 0.74 | CHEK2 (0.56) | CYP1A2CYP2D6CYP3A4ALDH1A1CYP2C19 | |
| SCHEMBL3910635 | 0.74 | ALK (0.53) | CYP1A2CYP2D6CYP3A4HSD17B10ALDH1A1 | |
| SCHEMBL13673955 | 0.74 | CYP1A2 (0.59) | CYP1A2CYP2D6CYP3A4ALOX15HSD17B10 | |
| SCHEMBL4513952 | 0.73 | CYP1A2 (0.74) | CYP1A2CYP2D6CYP3A4ALOX15HSD17B10 | |
| SCHEMBL1083888 | 0.73 | MAPK1 (0.73) | CYP1A2CYP2D6CYP3A4HSD17B10ALDH1A1 | |
| SCHEMBL13300259 | 0.73 | CYP1A2 (0.71) | CYP1A2CYP2D6CYP3A4ALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090247519-A1 | AMINO-ETHYL-AMINO-ARYL (AEAA) COMPOUNDS AND THEIR USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-10-01 | — | — | US | disclosed |
| US-20090247519-A1 | AMINO-ETHYL-AMINO-ARYL (AEAA) COMPOUNDS AND THEIR USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-10-01 | — | — | US | disclosed |
| US-20090247519-A1 | AMINO-ETHYL-AMINO-ARYL (AEAA) COMPOUNDS AND THEIR USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-10-01 | — | — | US | disclosed |
| WO-2007125331-A2 | AMINO-ETHYL-AMINO-ARYL (AEAA) COMPOUNDS AND THEIR USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2007-11-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247519-A1 | AMINO-ETHYL-AMINO-ARYL (AEAA) COMPOUNDS AND THEIR USE | PKD2, PKD1, AADAT | CYP1A2 3783/4885CYP2D6 3142/4885CYP3A4 4100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.