Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 17/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 16/20 | 0.78 |
| ▸ | CYP2D6 | P10635 | 14/20 | 0.78 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.78 |
| ▸ | ALOX15 | P16050 | 8/20 | 0.78 |
| ▸ | USP2 | O75604 | 8/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.78 |
| ▸ | CYP2C19 | P33261 | 12/20 | 0.72 |
| ▸ | TSHR | P16473 | 7/20 | 0.72 |
| ▸ | LMNA | P02545 | 6/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.70 |
| ▸ | CLK4 | Q9HAZ1 | 8/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13673955 | 0.86 | CYP1A2 (0.59) | CYP1A2CYP3A4CYP2D6HSD17B10ALOX15 | |
| SCHEMBL4520542 | 0.86 | CYP1A2 (0.59) | CYP1A2CYP3A4CYP2D6HSD17B10ALOX15 | |
| SCHEMBL4513952 | 0.85 | CYP1A2 (0.74) | CYP1A2CYP3A4CYP2D6HSD17B10ALOX15 | |
| SCHEMBL13300124 | 0.83 | CYP1A2 (0.73) | CYP1A2CYP3A4CYP2D6HSD17B10ALOX15 | |
| SCHEMBL1083851 | 0.81 | MEN1 (0.81) | CYP1A2CYP3A4CYP2D6HSD17B10ALOX15 | |
| SCHEMBL13300259 | 0.81 | CYP1A2 (0.71) | CYP1A2CYP3A4CYP2D6HSD17B10ALOX15 | |
| SCHEMBL13300257 | 0.81 | USP1 (0.55) | CYP1A2CYP3A4CYP2D6HSD17B10ALOX15 | |
| SCHEMBL3917004 | 0.81 | MEN1 (0.70) | CYP1A2CYP3A4CYP2D6HSD17B10ALOX15 | |
| SCHEMBL17770433 | 0.78 | PDE5A (0.73) | CYP1A2ALDH1A1MAPK1KDM4EMEN1 | |
| SCHEMBL4518374 | 0.78 | MEN1 (0.53) | CYP1A2CYP3A4CYP2D6HSD17B10ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090247519-A1 | AMINO-ETHYL-AMINO-ARYL (AEAA) COMPOUNDS AND THEIR USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-10-01 | — | — | US | disclosed |
| US-20090247519-A1 | AMINO-ETHYL-AMINO-ARYL (AEAA) COMPOUNDS AND THEIR USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-10-01 | — | — | US | disclosed |
| US-20090247519-A1 | AMINO-ETHYL-AMINO-ARYL (AEAA) COMPOUNDS AND THEIR USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-10-01 | — | — | US | disclosed |
| WO-2007125331-A2 | AMINO-ETHYL-AMINO-ARYL (AEAA) COMPOUNDS AND THEIR USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2007-11-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247519-A1 | AMINO-ETHYL-AMINO-ARYL (AEAA) COMPOUNDS AND THEIR USE | PKD2, PKD1, AADAT | CYP1A2 3783/4885CYP3A4 4100/4885CYP2D6 3142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.