SCHEMBL4520801

SCHEMBL4520801

CC(C)(C)OC(=O)N1CCC(CCN2CCN(c3ccc(C(=O)N4CCCCC4)cc3)CC2)CC1

nearest known ligand 0.59

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ABL1 P00519 1/20 0.59
RIN1 Q13671 1/20 0.59
GPR119 Q8TDV5 9/20 0.56
TGFBR1 P36897 3/20 0.51
MEN1 O00255 2/20 0.51
KMT2A Q03164 2/20 0.51
MBTD1 Q05BQ5 1/20 0.46
TP53BP1 Q12888 1/20 0.46
L3MBTL4 Q8NA19 1/20 0.46
L3MBTL3 Q96JM7 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
CYP2C19 P33261 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
POLB P06746 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4516799 0.99 ABL1 (0.58) ABL1RIN1GPR119TGFBR1MEN1
SCHEMBL4511902 0.92 GPR119 (0.56) ABL1RIN1GPR119TGFBR1MEN1
SCHEMBL4518799 0.90 GPR119 (0.52) ABL1RIN1GPR119TGFBR1MEN1
SCHEMBL4515215 0.89 GPR119 (0.51) ABL1RIN1GPR119TGFBR1MEN1
SCHEMBL4516328 0.88 GPR119 (0.54) ABL1RIN1GPR119TGFBR1MEN1
SCHEMBL4516324 0.88 GPR119 (0.54) ABL1RIN1GPR119TGFBR1MEN1
SCHEMBL4504053 0.88 GPR119 (0.60) GPR119TGFBR1MEN1KMT2ACYP2C19
SCHEMBL4515782 0.87 GPR119 (0.74) GPR119TGFBR1MEN1KMT2ACYP2C19
SCHEMBL7366692 0.85 GPR119 (0.59) GPR119TGFBR1
SCHEMBL4524071 0.85 GPR119 (0.51) ABL1RIN1GPR119TGFBR1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090203676-A1 G-protein Coupled Receptor Agonists PROSIDION LIMITED (GB) 2009-08-13 US disclosed
US-20090203676-A1 G-protein Coupled Receptor Agonists PROSIDION LIMITED (GB) 2009-08-13 US disclosed
US-20090203676-A1 G-protein Coupled Receptor Agonists PROSIDION LIMITED (GB) 2009-08-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090203676-A1 G-protein Coupled Receptor Agonists GPR119, GCGR, GPBAR1 ABL1 3033/4885RIN1 1624/4885GPR119 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.