Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | UBE2N | P61088 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | PNP | P00491 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4522972 | 0.89 | UBE2N (0.45) | KDM4EKMT2AHSD17B10ALDH1A1UBE2N | |
| SCHEMBL4518521 | 0.86 | UBE2N (0.45) | KDM4EKMT2AHSD17B10ALDH1A1UBE2N | |
| SCHEMBL4514150 | 0.85 | UBE2N (0.44) | KDM4EKMT2AHSD17B10ALDH1A1UBE2N | |
| SCHEMBL4529448 | 0.82 | UBE2N (0.42) | KDM4EKMT2AHSD17B10ALDH1A1UBE2N | |
| SCHEMBL4519785 | 0.82 | UBE2N (0.43) | KDM4EKMT2AHSD17B10ALDH1A1UBE2N | |
| SCHEMBL4514740 | 0.79 | HTR2A (0.39) | KDM4EKMT2AHSD17B10ALDH1A1UBE2N | |
| SCHEMBL4520660 | 0.77 | TSHR (0.49) | KDM4EALDH1A1TP53POLBMAPK1 | |
| SCHEMBL4505706 | 0.76 | S1PR5 (0.39) | KDM4EALDH1A1CHRM2CHRM4CHRM1 | |
| Hydrochloric Acid SCHEMBL4516965 | 0.75 | KDM4E (0.44) | KDM4EKMT2AALDH1A1POLBMAPK1 | |
| SCHEMBL5421524 | 0.75 | ALDH1A1 (0.42) | HSD17B10ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090275555-A1 | Substituted indole ligands for the ORL-1 receptor | BRANE DISCOVERY S.R.L. (IT) | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275555-A1 | Substituted indole ligands for the ORL-1 receptor | OGFRL1, OPRL1, ORMDL3 | KDM4E 4525/4885KMT2A 3625/4885HSD17B10 2560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.