Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UBE2N | P61088 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | AVPR1B | P47901 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4529448 | 0.91 | UBE2N (0.42) | UBE2NTDP1POLBKMT2AL3MBTL1 | |
| SCHEMBL4518521 | 0.87 | UBE2N (0.45) | UBE2NTDP1POLBKMT2AL3MBTL1 | |
| SCHEMBL4522972 | 0.85 | UBE2N (0.45) | UBE2NTDP1POLBKMT2AL3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL4505995 | 0.84 | UBE2N (0.45) | UBE2NTDP1POLBKMT2AL3MBTL1 | |
| SCHEMBL4514150 | 0.84 | UBE2N (0.44) | UBE2NTDP1POLBKMT2AL3MBTL1 | |
| SCHEMBL4521541 | 0.82 | KDM4E (0.45) | UBE2NTDP1POLBKMT2AL3MBTL1 | |
| SCHEMBL4514740 | 0.81 | HTR2A (0.39) | UBE2NTDP1POLBKMT2AMEN1 | |
| SCHEMBL4518923 | 0.80 | SIGMAR1 (0.48) | UBE2NTDP1POLBKMT2AL3MBTL1 | |
| SCHEMBL5421524 | 0.79 | ALDH1A1 (0.42) | POLBALDH1A1HSD17B10DRD4MCHR1 | |
| Hydrochloric Acid SCHEMBL5417840 | 0.78 | ALDH1A1 (0.41) | POLBTSHRALDH1A1HSD17B10DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090275555-A1 | Substituted indole ligands for the ORL-1 receptor | BRANE DISCOVERY S.R.L. (IT) | 2009-11-05 | — | — | US | claimed |
| US-20090275555-A1 | Substituted indole ligands for the ORL-1 receptor | BRANE DISCOVERY S.R.L. (IT) | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275555-A1 | Substituted indole ligands for the ORL-1 receptor | OGFRL1, OPRL1, ORMDL3 | UBE2N 2883/4885TDP1 2258/4885POLB 4604/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.