Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PRKCB | P05771 | 9/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTR1F | P30939 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4532323 | 0.87 | KMT2A (0.42) | ALDH1A1TP53NPC1RAB9APAK4 | |
| SCHEMBL4701327 | 0.75 | MAPT (0.42) | ALDH1A1LMNATP53MAPTSMN1; SMN2 | |
| SCHEMBL1204639 | 0.75 | ALDH1A1 (0.47) | ALDH1A1LMNATP53NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL4425813 | 0.74 | MAPT (0.42) | ALDH1A1LMNATP53MAPTSMN1; SMN2 | |
| SCHEMBL4291472 | 0.74 | FLT3 (0.40) | ALDH1A1NPC1RAB9AMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4291464 | 0.73 | FLT3 (0.40) | ALDH1A1NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL1206401 | 0.72 | MAPT (0.43) | ALDH1A1LMNARAB9AMAPTSMN1; SMN2 | |
| SCHEMBL1206305 | 0.71 | PAK4 (0.41) | ALDH1A1LMNAPRKCBTP53NPC1 | |
| SCHEMBL19305447 | 0.70 | — | — | |
| SCHEMBL12879065 | 0.69 | PAK4 (0.41) | ALDH1A1LMNAPRKCBMAPTPAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979356-B1 | CARBONYLAMINO PYRROLOPYRAZOLES, POTENT KINASE INHIBITORS | PFIZER PROD INC (US) | 2013-09-18 | — | — | EP | disclosed |
| US-20090318440-A1 | CARBONYLAMINO PYRROLOPYRAZOLES, POTENT KINASE INHIBITORS | PFIZER INC. | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318440-A1 | CARBONYLAMINO PYRROLOPYRAZOLES, POTENT KINASE INHIBITORS | PAK4, PAK5, PAK3 | ALDH1A1 2240/4885LMNA 3611/4885PRKCB 132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.