Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4425813 | 0.99 | MAPT (0.42) | MAPTLMNAALDH1A1SMN1; SMN2GAA | |
| SCHEMBL4284883 | 0.89 | KDM4E (0.45) | MAPTLMNASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL4286497 | 0.88 | MAPT (0.38) | MAPTLMNAALDH1A1SMN1; SMN2GAA | |
| SCHEMBL4424639 | 0.88 | ALDH1A1 (0.48) | MAPTLMNAALDH1A1SMN1; SMN2GAA | |
| Hydrochloric Acid SCHEMBL4286492 | 0.88 | MAPT (0.37) | MAPTLMNAALDH1A1SMN1; SMN2GAA | |
| SCHEMBL1206304 | 0.88 | ALDH1A1 (0.40) | MAPTLMNAALDH1A1SMN1; SMN2GAA | |
| Hydrochloric Acid SCHEMBL4424633 | 0.87 | ALDH1A1 (0.48) | MAPTLMNAALDH1A1SMN1; SMN2GAA | |
| SCHEMBL1371503 | 0.86 | SIRT6 (0.42) | MAPTLMNAALDH1A1SMN1; SMN2POLB | |
| SCHEMBL4278090 | 0.85 | MAPT (0.41) | MAPTLMNAALDH1A1SMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL1371499 | 0.85 | SIRT6 (0.42) | MAPTLMNAALDH1A1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461193-B2 | Substituted pyrrolo-pyrazole derivatives active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-06-11 | — | — | US | disclosed |
| EP-1963326-A1 | SUBSTITUTED PYRROLO-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007068637-A1 | SUBSTITUTED PYRROLO-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2007-06-21 | — | — | WO | disclosed |