Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 8/20 | 0.65 |
| ▸ | WNT1 | P04628 | 6/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | FLT3 | P36888 | 6/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | MARK3 | P27448 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4523182 | 0.87 | DYRK1A (0.67) | DYRK1AWNT1FLT3MMP9DYRK3 | |
| SCHEMBL82655 | 0.84 | DYRK1A (0.70) | DYRK1AWNT1FLT3DYRK3MAP4K4 | |
| SCHEMBL6221286 | 0.81 | CDK2 (0.65) | DYRK1AWNT1FLT3DYRK3MAP4K4 | |
| SCHEMBL4531298 | 0.80 | CDK2 (0.59) | DYRK1AWNT1FLT3MMP9DYRK3 | |
| SCHEMBL953365 | 0.79 | DYRK1A (0.61) | DYRK1AWNT1FLT3DYRK3MAP4K4 | |
| SCHEMBL17096021 | 0.79 | DYRK1A (1.00) | DYRK1AWNT1CDK1CLK2GSK3B | |
| Hydrochloric Acid SCHEMBL955121 | 0.78 | DYRK1A (0.60) | DYRK1AWNT1FLT3DYRK3MAP4K4 | |
| SCHEMBL4532307 | 0.77 | TP53 (0.45) | RAB9AL3MBTL1TP53SMN1; SMN2MMP9 | |
| SCHEMBL4523358 | 0.77 | DYRK1A (0.58) | DYRK1AWNT1CLK2 | |
| SCHEMBL6221471 | 0.77 | DYRK1A (0.62) | DYRK1AWNT1FLT3DYRK3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482342-B2 | Indazolecarboxamide derivatives, preparation and use thereof as CDK1, CDK2 and CDK4 inhibitors | SANOFI-AVENTIS (FR) | 2009-01-27 | — | — | US | disclosed |
| US-20060004000-A1 | Indazolecarboxamide derivatives, preparation and use thereof as CDK1, CDK2 and CDK4 inhibitors | SANOFI-AVENTIS (FR) | 2006-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060004000-A1 | Indazolecarboxamide derivatives, preparation and use thereof as CDK1, CDK2 and CDK4 inhibitors | CDK2, CDK1, CDK4 | DYRK1A 425/4885WNT1 364/4885RAB9A 4086/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.