Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 3/20 | 0.59 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.58 |
| ▸ | WNT1 | P04628 | 6/20 | 0.58 |
| ▸ | MMP9 | P14780 | 2/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | MARK3 | P27448 | 1/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.46 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.46 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.46 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.46 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.46 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.46 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6221286 | 0.95 | CDK2 (0.65) | CDK2DYRK1AWNT1CSNK2A1DYRK3 | |
| SCHEMBL4523182 | 0.92 | DYRK1A (0.67) | CDK2DYRK1AWNT1MMP9CSNK2A1 | |
| SCHEMBL82655 | 0.82 | DYRK1A (0.70) | CDK2DYRK1AWNT1CSNK2A1DYRK3 | |
| SCHEMBL4522971 | 0.80 | DYRK1A (0.65) | CDK2DYRK1AWNT1MMP9CSNK2A1 | |
| SCHEMBL29843032 | 0.76 | CDK2 (1.00) | CDK2CSNK2A1FLT3CCNA2CCNA1 | |
| SCHEMBL4524087 | 0.76 | CDK2 (1.00) | CDK2CSNK2A1FLT3CCNA2CCNA1 | |
| SCHEMBL6221471 | 0.75 | DYRK1A (0.62) | CDK2DYRK1AWNT1CSNK2A1DYRK3 | |
| SCHEMBL17096021 | 0.74 | DYRK1A (1.00) | DYRK1AWNT1CDK1CLK2GSK3B | |
| SCHEMBL4523358 | 0.74 | DYRK1A (0.58) | DYRK1AWNT1CLK2 | |
| SCHEMBL5916093 | 0.73 | DYRK1A (0.62) | CDK2DYRK1AWNT1CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482342-B2 | Indazolecarboxamide derivatives, preparation and use thereof as CDK1, CDK2 and CDK4 inhibitors | SANOFI-AVENTIS (FR) | 2009-01-27 | — | — | US | disclosed |