Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 18/20 | 0.58 |
| ▸ | WNT1 | P04628 | 16/20 | 0.58 |
| ▸ | CLK2 | P49760 | 6/20 | 0.52 |
| ▸ | CLK3 | P49761 | 6/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | CSF1R | P07333 | 1/20 | 0.50 |
| ▸ | IGF1R | P08069 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | KIT | P10721 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | FLT1 | P17948 | 1/20 | 0.50 |
| ▸ | FLT4 | P35916 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | TEK | Q02763 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL82407 | 0.93 | DYRK1A (0.66) | DYRK1AWNT1CLK2CLK3 | |
| SCHEMBL82655 | 0.90 | DYRK1A (0.70) | DYRK1AWNT1CLK2CLK3ABL1 | |
| SCHEMBL4514663 | 0.88 | DYRK1A (0.52) | DYRK1AWNT1CLK2CLK3ABL1 | |
| SCHEMBL4533934 | 0.81 | FLT1 (0.54) | DYRK1AWNT1CLK2CLK3ABL1 | |
| SCHEMBL4523182 | 0.80 | DYRK1A (0.67) | DYRK1AWNT1CLK2CLK3 | |
| SCHEMBL953365 | 0.79 | DYRK1A (0.61) | DYRK1AWNT1CLK2CLK3ABL1 | |
| SCHEMBL6219544 | 0.79 | DYRK1A (0.72) | DYRK1AWNT1CLK2CLK3 | |
| SCHEMBL6221664 | 0.79 | DYRK1A (0.68) | DYRK1AWNT1CLK2CLK3 | |
| Hydrochloric Acid SCHEMBL955121 | 0.79 | DYRK1A (0.60) | DYRK1AWNT1CLK2CLK3ABL1 | |
| Hydrochloric Acid SCHEMBL5915919 | 0.78 | DYRK1A (0.49) | DYRK1AWNT1CLK2CLK3ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482342-B2 | Indazolecarboxamide derivatives, preparation and use thereof as CDK1, CDK2 and CDK4 inhibitors | SANOFI-AVENTIS (FR) | 2009-01-27 | — | — | US | claimed |