Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.64 |
| ▸ | POLA1 | P09884 | 1/20 | 0.64 |
| ▸ | POLD1 | P28340 | 1/20 | 0.64 |
| ▸ | TK1 | P04183 | 4/20 | 0.54 |
| ▸ | DTYMK | P23919 | 4/20 | 0.49 |
| ▸ | TYMS | P04818 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15343781 | 0.93 | POLB (0.67) | POLBPOLA1POLD1TK1DTYMK | |
| SCHEMBL18790013 | 0.93 | POLB (0.67) | POLBPOLA1POLD1TK1DTYMK | |
| SCHEMBL2148399 | 0.93 | POLB (0.67) | POLBPOLA1POLD1TK1DTYMK | |
| SCHEMBL427926 | 0.93 | POLB (0.67) | POLBPOLA1POLD1TK1DTYMK | |
| SCHEMBL26571269 | 0.88 | POLB (0.68) | POLBPOLA1POLD1TK1DTYMK | |
| SCHEMBL26479965 | 0.88 | POLB (0.68) | POLBPOLA1POLD1TK1DTYMK | |
| SCHEMBL26571270 | 0.88 | POLB (0.68) | POLBPOLA1POLD1TK1DTYMK | |
| SCHEMBL20997626 | 0.88 | POLB (0.68) | POLBPOLA1POLD1TK1DTYMK | |
| SCHEMBL19928649 | 0.88 | POLB (0.60) | POLBPOLA1POLD1TK1DTYMK | |
| SCHEMBL24370822 | 0.86 | POLB (0.72) | POLBPOLA1POLD1TK1DTYMK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9909177-B2 | Pyrosequencing methods and related compositions | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-03-06 | — | — | US | disclosed |
| US-20160312279-A1 | PYROSEQUENCING METHODS AND RELATED COMPOSITIONS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2016-10-27 | — | — | US | disclosed |
| US-9169510-B2 | Pyrosequencing methods and related compositions | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-10-27 | — | — | US | disclosed |
| US-20090325154-A1 | Pyrosequencing Methods and Related Compositions | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2009-12-31 | — | — | US | disclosed |
| WO-2007002204-A2 | PYROSEQUENCING METHODS AND RELATED COMPOSTIONS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2007-01-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325154-A1 | Pyrosequencing Methods and Related Compositions | RNGTT, DNMT3A, NT5C3B | POLB 4/4885POLA1 47/4885POLD1 115/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.