Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 18/20 | 0.51 |
| ▸ | THRA | P10827 | 16/20 | 0.51 |
| ▸ | RORC | P51449 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4529401 | 0.86 | THRA (0.62) | THRBTHRA | |
| SCHEMBL4523202 | 0.85 | THRB (0.54) | THRBTHRARORC | |
| SCHEMBL4524227 | 0.75 | THRB (0.77) | THRBTHRARORC | |
| SCHEMBL5387736 | 0.74 | THRB (0.56) | THRBTHRARORC | |
| SCHEMBL2786735 | 0.73 | THRB (0.61) | THRBTHRA | |
| SCHEMBL2785262 | 0.73 | THRB (0.61) | THRBTHRA | |
| SCHEMBL2785259 | 0.73 | THRB (0.61) | THRBTHRA | |
| SCHEMBL5406589 | 0.72 | THRB (0.58) | THRBTHRARORC | |
| SCHEMBL7194241 | 0.70 | THRA (0.74) | THRBTHRA | |
| SCHEMBL4359309 | 0.70 | THRA (0.71) | THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080835-A1 | THYROMIMETRIC COMPOUNDS IN TREATMENT OF DISEASE RELATED TO SONIC HEDGEHOG SIGNALLING | KARO BIO AB (SE) | 2009-07-02 | — | — | WO | disclosed |
| EP-1296936-A1 | THYROID RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND THEIR USE IN THE TREATMENT OF DISORDERS INFLUENCED BY THYROID HORMONES | KARO BIO AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2001098256-A1 | THYROID RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND THEIR USE IN THE TREATMENT OF DISORDERS INFLUENCED BY THYROID HORMONES | KARO BIO AB (SE) | 2001-12-27 | — | — | WO | disclosed |