Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 14/20 | 0.52 |
| ▸ | WNT1 | P04628 | 13/20 | 0.52 |
| ▸ | ITK | Q08881 | 3/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | TEK | Q02763 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 6/20 | 0.46 |
| ▸ | CLK3 | P49761 | 6/20 | 0.46 |
| ▸ | ATR | Q13535 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6221471 | 0.90 | DYRK1A (0.62) | DYRK1AWNT1ITKAURKAABL1 | |
| SCHEMBL4523358 | 0.88 | DYRK1A (0.58) | DYRK1AWNT1ABL1CSF1RIGF1R | |
| SCHEMBL82407 | 0.88 | DYRK1A (0.66) | DYRK1AWNT1CLK2CLK3 | |
| SCHEMBL953365 | 0.79 | DYRK1A (0.61) | DYRK1AWNT1ABL1CSF1RIGF1R | |
| Hydrochloric Acid SCHEMBL955121 | 0.79 | DYRK1A (0.60) | DYRK1AWNT1ABL1CSF1RIGF1R | |
| SCHEMBL82655 | 0.77 | DYRK1A (0.70) | DYRK1AWNT1ABL1CSF1RIGF1R | |
| SCHEMBL6219544 | 0.74 | DYRK1A (0.72) | DYRK1AWNT1CLK2CLK3 | |
| SCHEMBL4523182 | 0.73 | DYRK1A (0.67) | DYRK1AWNT1CLK2CLK3 | |
| SCHEMBL14785564 | 0.73 | DYRK1A (0.69) | DYRK1AWNT1CLK2CLK3 | |
| SCHEMBL82445 | 0.72 | LRRK2 (0.56) | DYRK1AWNT1ITKAURKACLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060004000-A1 | Indazolecarboxamide derivatives, preparation and use thereof as CDK1, CDK2 and CDK4 inhibitors | SANOFI-AVENTIS (FR) | 2006-01-05 | — | — | US | claimed |
| US-7482342-B2 | Indazolecarboxamide derivatives, preparation and use thereof as CDK1, CDK2 and CDK4 inhibitors | SANOFI-AVENTIS (FR) | 2009-01-27 | — | — | US | disclosed |
| US-20060004000-A1 | Indazolecarboxamide derivatives, preparation and use thereof as CDK1, CDK2 and CDK4 inhibitors | SANOFI-AVENTIS (FR) | 2006-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060004000-A1 | Indazolecarboxamide derivatives, preparation and use thereof as CDK1, CDK2 and CDK4 inhibitors | CDK2, CDK1, CDK4 | DYRK1A 425/4885WNT1 364/4885ITK 4137/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.