SCHEMBL4524813

SCHEMBL4524813

CC1(C)CC(=O)C2=C(C1)N=CC2(C)c1ccc(C(N)=O)c(NCc2ccncc2)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDC7 O00311 2/20 0.45
ROCK2 O75116 2/20 0.45
MAP4K4 O95819 2/20 0.45
GSK3B P49841 2/20 0.45
CLK4 Q9HAZ1 2/20 0.45
MKNK2 Q9HBH9 2/20 0.45
CDK2 P24941 2/20 0.42
PIM1 P11309 1/20 0.42
BUB1 O43683 2/20 0.40
GAA P10253 1/20 0.39
HSP90AA1 P07900 10/20 0.34
HSP90AB1 P08238 10/20 0.34
TRAP1 Q12931 6/20 0.34
HSP90B1 P14625 5/20 0.34
POLB P06746 1/20 0.33
KMT2A Q03164 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
CCNA2 P20248 1/20 0.33
CCNA1 P78396 1/20 0.33
MKNK1 Q9BUB5 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4539183 0.84 HSP90AA1 (0.48) BUB1HSP90AA1HSP90AB1TRAP1HSP90B1
SCHEMBL4523147 0.79 HSP90AA1 (0.54) HSP90AA1HSP90AB1TRAP1HSP90B1
SCHEMBL4535145 0.78 HSP90AA1 (0.55) HSP90AA1HSP90AB1TRAP1HSP90B1
SCHEMBL4536660 0.77 KDM4E (0.44) CDC7ROCK2MAP4K4GSK3BCLK4
SCHEMBL4526380 0.76 HSP90AA1 (0.55) CDC7ROCK2MAP4K4GSK3BCLK4
SCHEMBL4526880 0.74 HSP90AA1 (0.47) HSP90AA1HSP90AB1TRAP1HSP90B1
SCHEMBL4529101 0.73 KDM4E (0.43) CDC7ROCK2MAP4K4GSK3BCLK4
SCHEMBL5279605 0.70 HSP90AA1 (0.43) HSP90AA1HSP90AB1TRAP1HSP90B1
SCHEMBL1218856 0.70 HSP90AB1 (0.64) HSP90AA1HSP90AB1TRAP1HSP90B1
SCHEMBL4531034 0.67 HSP90AA1 (0.42) BUB1HSP90AA1HSP90AB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4377942-B2 2009-12-02 JP claimed
JP-2008531599-A 2008-08-14 JP claimed
EP-1856057-A1 TETRAHYDROINDOLONE AND TETRAHYDROINDAZOLONE DERIVATIVES Serenex, Inc. (US) 2007-11-21 EP claimed
WO-2006091963-A1 TETRAHYDROINDOLONE AND TETRAHYDROINDAZOLONE DERIVATIVES SERENEX, INC. (US) 2006-08-31 WO claimed