SCHEMBL4539183

SCHEMBL4539183

COCCNc1cc(C2(C)C=NC3=C2C(=O)CC(C)(C)C3)ccc1C(N)=O

nearest known ligand 0.48

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 17/20 0.48
HSP90AB1 P08238 15/20 0.48
TRAP1 Q12931 6/20 0.48
HSP90B1 P14625 5/20 0.37
PTGER4 P35408 1/20 0.33
BUB1 O43683 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4524813 0.84 CDC7 (0.45) HSP90AA1HSP90AB1TRAP1HSP90B1BUB1
SCHEMBL4526380 0.80 HSP90AA1 (0.55) HSP90AA1HSP90AB1BUB1
SCHEMBL4527690 0.79 HSP90AA1 (0.44) HSP90AA1HSP90AB1TRAP1HSP90B1
SCHEMBL4523147 0.79 HSP90AA1 (0.54) HSP90AA1HSP90AB1TRAP1HSP90B1
SCHEMBL4579698 0.70 HSP90AA1 (0.59) HSP90AA1HSP90AB1TRAP1HSP90B1
SCHEMBL1220737 0.70 HSP90AB1 (0.65) HSP90AA1HSP90AB1TRAP1HSP90B1
SCHEMBL1221343 0.69 HSP90AB1 (0.68) HSP90AA1HSP90AB1TRAP1HSP90B1
SCHEMBL1220230 0.69 HSP90AB1 (0.67) HSP90AA1HSP90AB1TRAP1HSP90B1
SCHEMBL4536660 0.69 KDM4E (0.44)
SCHEMBL4531034 0.67 HSP90AA1 (0.42) HSP90AA1HSP90AB1BUB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4377942-B2 2009-12-02 JP claimed
JP-2008531599-A 2008-08-14 JP claimed
EP-1856057-A1 TETRAHYDROINDOLONE AND TETRAHYDROINDAZOLONE DERIVATIVES Serenex, Inc. (US) 2007-11-21 EP claimed
WO-2006091963-A1 TETRAHYDROINDOLONE AND TETRAHYDROINDAZOLONE DERIVATIVES SERENEX, INC. (US) 2006-08-31 WO claimed