Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 2/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | BUB1 | O43683 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4535495 | 0.86 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1JAK2JAK1TYK2 | |
| SCHEMBL4536660 | 0.79 | KDM4E (0.44) | JAK2JAK3KDM4EALDH1A1 | |
| SCHEMBL4534406 | 0.76 | HSP90AA1 (0.35) | HSP90AA1HSP90AB1BRD4 | |
| SCHEMBL4526380 | 0.73 | HSP90AA1 (0.55) | HSP90AA1HSP90AB1JAK2JAK1TYK2 | |
| SCHEMBL4523147 | 0.68 | HSP90AA1 (0.54) | HSP90AA1HSP90AB1 | |
| SCHEMBL4524813 | 0.67 | CDC7 (0.45) | HSP90AA1HSP90AB1BUB1 | |
| SCHEMBL27952336 | 0.65 | SIRT2 (0.54) | HSP90AA1HSP90AB1SIRT2SIRT1BRD4 | |
| SCHEMBL1220887 | 0.65 | HSP90AA1 (0.73) | HSP90AA1HSP90AB1BRD4KDM4EALDH1A1 | |
| SCHEMBL1220822 | 0.64 | HSP90AA1 (0.74) | HSP90AA1HSP90AB1SIRT2SIRT1BRD4 | |
| SCHEMBL1220662 | 0.64 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4377942-B2 | — | — | 2009-12-02 | — | — | JP | claimed |
| JP-2008531599-A | — | — | 2008-08-14 | — | — | JP | claimed |
| EP-1856057-A1 | TETRAHYDROINDOLONE AND TETRAHYDROINDAZOLONE DERIVATIVES | Serenex, Inc. (US) | 2007-11-21 | — | — | EP | claimed |
| WO-2006091963-A1 | TETRAHYDROINDOLONE AND TETRAHYDROINDAZOLONE DERIVATIVES | SERENEX, INC. (US) | 2006-08-31 | — | — | WO | claimed |