Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IP6K1 | Q92551 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | F10 | P00742 | 3/20 | 0.38 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.37 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL45554 | 0.88 | THRA (0.42) | MAPTRAB9AGAA | |
| SCHEMBL40377 | 0.85 | IP6K1 (0.44) | IP6K1MAPTF10BMPR1BBMPR1A | |
| SCHEMBL40209 | 0.79 | SCN10A (0.44) | IP6K1MAPTF10HDAC1SCN10A | |
| SCHEMBL40233 | 0.74 | HPGD (0.47) | MAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL40407 | 0.69 | IP6K1 (0.46) | IP6K1MAPTBMPR1BBMPR1ATGFBR1 | |
| SCHEMBL28168973 | 0.69 | LRRK2 (0.49) | IP6K1MAPTF10RAB9AHDAC1 | |
| SCHEMBL17690691 | 0.68 | PHGDH (0.40) | IP6K1MAPTRAB9ASMN1; SMN2JAK2 | |
| SCHEMBL10149225 | 0.68 | IP6K1 (0.53) | IP6K1MAPTF10BMPR1BBMPR1A | |
| SCHEMBL17779283 | 0.68 | IP6K1 (0.66) | IP6K1MAPTRAB9AHDAC1GAA | |
| SCHEMBL1696908 | 0.68 | SERPINE1 (0.43) | MAPTF10GAASCN10ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2591354-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |