Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 5/20 | 0.42 |
| ▸ | THRB | P10828 | 4/20 | 0.42 |
| ▸ | SIRT6 | Q8N6T7 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 7/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL45249 | 0.88 | IP6K1 (0.41) | MAPTGAARAB9A | |
| SCHEMBL40233 | 0.86 | HPGD (0.47) | SIRT6MAPTHPGDCYP1A2CYP2C9 | |
| SCHEMBL1696908 | 0.80 | SERPINE1 (0.43) | SIRT6MAPTKMT2AMEN1FAAH | |
| SCHEMBL17493124 | 0.75 | SIRT6 (0.48) | THRBSIRT6MAPTHPGDCYP1A2 | |
| SCHEMBL40377 | 0.74 | IP6K1 (0.44) | MAPTALDH1A1KMT2AMAPK1GAA | |
| SCHEMBL1696925 | 0.71 | HPGD (0.49) | SIRT6MAPTHPGDCYP1A2CYP2C9 | |
| SCHEMBL17493077 | 0.71 | SIRT6 (0.48) | SIRT6MAPTHPGDCYP1A2CYP2C9 | |
| SCHEMBL28168960 | 0.70 | SIRT6 (0.47) | THRBSIRT6MAPTHPGDCYP1A2 | |
| SCHEMBL40388 | 0.70 | SIRT6 (0.55) | THRBSIRT6MAPTCYP1A2CYP2C19 | |
| SCHEMBL17493040 | 0.69 | SIRT6 (0.52) | THRBSIRT6MAPTHPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2591354-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |