Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.34 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.34 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.34 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.34 |
| ▸ | GRIK4 | Q16099 | 1/20 | 0.34 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.34 |
| ▸ | PLA2G4A | P47712 | 2/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | FDPS | P14324 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27554566 | 0.76 | CYP3A4 (0.33) | — | |
| Histidine SCHEMBL10879497 | 0.75 | CYP1A2 (0.47) | ALDH1A1GRIK1GRIA1GRIA2GRIA3 | |
| Hydrochloric Acid SCHEMBL9767650 | 0.75 | CYP1A2 (0.34) | — | |
| Histidine SCHEMBL4406902 | 0.75 | CYP1A2 (0.47) | ALDH1A1GRIK1GRIA1GRIA2GRIA3 | |
| Histidine SCHEMBL3258 | 0.75 | SLC7A5 (0.47) | ALDH1A1GRIK1GRIA1GRIA2GRIA3 | |
| Histidine SCHEMBL3259 | 0.75 | SLC7A5 (0.47) | ALDH1A1GRIK1GRIA1GRIA2GRIA3 | |
| Histidine SCHEMBL163442 | 0.75 | SLC7A5 (0.47) | ALDH1A1GRIK1GRIA1GRIA2GRIA3 | |
| Histidine SCHEMBL163443 | 0.75 | SLC7A5 (0.47) | ALDH1A1GRIK1GRIA1GRIA2GRIA3 | |
| Histidine SCHEMBL18824897 | 0.75 | SLC7A5 (0.47) | ALDH1A1GRIK1GRIA1GRIA2GRIA3 | |
| Histidine SCHEMBL388563 | 0.75 | SLC7A5 (0.47) | ALDH1A1GRIK1GRIA1GRIA2GRIA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8802861-B2 | Thiazole derivatives and use thereof | MERCK SERONO SA (CH) | 2014-08-12 | — | — | US | disclosed |
| US-20090029998-A1 | Thiazole Derivatives and Use Thereof | APPLIED RESEARCH SYSTEM ARS HOLDING N.V. (NL) | 2009-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090029998-A1 | Thiazole Derivatives and Use Thereof | PDGFRB, PDGFRA, TEC | ALDH1A1 174/4885GRIK1 1663/4885GRIA1 600/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.