Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12468637 | 0.79 | HPGD (0.63) | LMNAMAPK1HPGDCES2CES1 | |
| SCHEMBL2249346 | 0.79 | HPGD (0.63) | LMNAMAPK1HPGDCES2CES1 | |
| SCHEMBL13849535 | 0.79 | HPGD (0.63) | LMNAMAPK1HPGDCES2CES1 | |
| SCHEMBL4631540 | 0.77 | LMNA (0.56) | LMNAMAPK1HPGDCES2CES1 | |
| SCHEMBL10536611 | 0.77 | LMNA (0.62) | LMNAMAPK1HPGDCES2CES1 | |
| SCHEMBL10865453 | 0.77 | LMNA (0.62) | LMNAMAPK1HPGDCES2CES1 | |
| SCHEMBL2971437 | 0.75 | HPGD (0.70) | LMNAMAPK1HPGDCES2CES1 | |
| SCHEMBL1562538 | 0.75 | HPGD (0.70) | LMNAMAPK1HPGDCES2CES1 | |
| SCHEMBL13255670 | 0.75 | HPGD (0.53) | LMNAMAPK1HPGDCES2CES1 | |
| SCHEMBL5858513 | 0.75 | HPGD (0.70) | LMNAMAPK1HPGDCES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5541196-A | ANTIPROTOZOA AGENTS | INSTITUT FRANCAIS DE RECHERCHE SCIENTIFIQUE POUR LE DEVELOPPMENT EN COOPERATION (ORSTOM) (FR) | 1996-07-30 | — | — | US | claimed |
| EP-3527573-B1 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | GILEAD SCIENCES INC (US) | 2020-08-12 | — | — | EP | disclosed |
| EP-2241564-A1 | 3,8-DIAMINOTETRAHYDROQUINOLINE DERIVATIVE | Zeria Pharmaceutical Co., Ltd. (JP) | 2010-10-20 | — | — | EP | disclosed |
| US-20090081590-A1 | NEGATIVE RESIST COMPOSITION AND PROCESS FOR FORMING RESIST PATTERNS | TOKYO OHKA KOGYO CO., LTD. (JP) | 2009-03-26 | — | — | US | disclosed |
| US-5700802-A | Furopyridine derivatives | MERCK SHARP & DOHME, LTD. (GB) | 1997-12-23 | — | — | US | disclosed |
| US-5681836-A | Methanesulfonate salts of antipsychotic benzofuran derivatives | MERCK, SHARP & DOHME, LTD. (GB) | 1997-10-28 | — | — | US | disclosed |
| US-5665722-A | Benzofuran derivatives as D4 receptor antagonists | MERCK, SHARP & DOHME, LTD. (GB) | 1997-09-09 | — | — | US | disclosed |
| EP-0757686-A1 | BENZOFURAN DERIVATIVES AS D 4? RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 1997-02-12 | — | — | EP | disclosed |
| WO-1995029911-A1 | BENZOFURAN DERIVATIVES AS D4 RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1995-11-09 | — | — | WO | disclosed |