Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 13/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 13/20 | 0.63 |
| ▸ | CLK4 | Q9HAZ1 | 7/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 10/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.60 |
| ▸ | HPGD | P15428 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | DHFR | P00374 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 8/20 | 0.51 |
| ▸ | TSHR | P16473 | 6/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 7/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.49 |
| ▸ | RAF1 | P04049 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4533398 | 0.91 | CYP1A2 (0.56) | CYP1A2CYP3A4CLK4CYP2C19CYP2D6 | |
| SCHEMBL4527555 | 0.82 | DHFR (0.54) | HPGDSMN1; SMN2DHFRMAPK1MEN1 | |
| SCHEMBL4356012 | 0.81 | CYP1A2 (0.60) | CYP1A2CYP3A4CLK4CYP2C19CYP2D6 | |
| SCHEMBL4532712 | 0.81 | DHFR (0.61) | CYP1A2CYP3A4CLK4CYP2C19DHFR | |
| SCHEMBL4528809 | 0.81 | DHFR (0.65) | CYP1A2DHFR | |
| SCHEMBL4530789 | 0.80 | LIMK1 (0.50) | CYP1A2CYP3A4CLK4DHFRKDM1A | |
| SCHEMBL4905355 | 0.78 | CYP1A2 (0.57) | CYP1A2CYP3A4CLK4CYP2C19CYP2D6 | |
| SCHEMBL4532427 | 0.77 | DHFR (0.46) | DHFRLMNAKDM4E | |
| SCHEMBL4524726 | 0.77 | DHFR (0.46) | DHFR | |
| Trifluoroacetic Acid SCHEMBL4533807 | 0.76 | MAP4K4 (0.47) | SMN1; SMN2DHFRMAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090105477-A1 | Quinazoline Protein Tyrosine Phosphatase Inhibitors | BERTHEL STEVEN JOSEPH | 2009-04-23 | — | — | US | claimed |
| US-20060211715-A1 | Quinazoline protein tyrosine phosphatase inhibitors | BERTHEL STEVEN J | 2006-09-21 | — | — | US | claimed |
| US-20090105477-A1 | Quinazoline Protein Tyrosine Phosphatase Inhibitors | BERTHEL STEVEN JOSEPH | 2009-04-23 | — | — | US | disclosed |
| US-20090105477-A1 | Quinazoline Protein Tyrosine Phosphatase Inhibitors | BERTHEL STEVEN JOSEPH | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105477-A1 | Quinazoline Protein Tyrosine Phosphatase Inhibitors | PTPN5, PTPN1, PTPN7 | CYP1A2 671/4885CYP3A4 1394/4885CLK4 1985/4885 |
| US-20060211715-A1 | Quinazoline protein tyrosine phosphatase inhibitors | PTPN5, PTPN1, PTPN7 | CYP1A2 671/4885CYP3A4 1394/4885CLK4 1985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.