Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 7/20 | 0.65 |
| ▸ | TRIM58 | Q8NG06 | 1/20 | 0.56 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 3/20 | 0.48 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.45 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4532712 | 0.97 | DHFR (0.61) | DHFRTRIM58HRH4MAP4K4APP | |
| SCHEMBL4519688 | 0.90 | DHFR (0.52) | DHFRTRIM58HRH4MAP4K4APP | |
| Trifluoroacetic Acid SCHEMBL4525618 | 0.89 | DHFR (0.52) | DHFRTRIM58HRH4MAP4K4APP | |
| Trifluoroacetic Acid SCHEMBL4528549 | 0.87 | DHFR (0.50) | DHFRTRIM58HRH4MAP4K4APP | |
| SCHEMBL4525495 | 0.84 | DHFR (0.47) | DHFRTRIM58HRH4MAP4K4NLRP3 | |
| SCHEMBL4532427 | 0.84 | DHFR (0.46) | DHFRTRIM58HRH4MAP4K4NLRP3 | |
| SCHEMBL4524726 | 0.84 | DHFR (0.46) | DHFRTRIM58HRH4MAP4K4APP | |
| SCHEMBL4515183 | 0.83 | PTPN1 (0.59) | DHFRCYP1A2PTPN1 | |
| SCHEMBL4521004 | 0.83 | ALDH1A1 (0.59) | DHFRHRH4MAP4K4NLRP3CYP1A2 | |
| SCHEMBL4522624 | 0.83 | DHFR (0.45) | DHFRMAP4K4APPNLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090105477-A1 | Quinazoline Protein Tyrosine Phosphatase Inhibitors | BERTHEL STEVEN JOSEPH | 2009-04-23 | — | — | US | claimed |
| US-20060211715-A1 | Quinazoline protein tyrosine phosphatase inhibitors | BERTHEL STEVEN J | 2006-09-21 | — | — | US | claimed |
| US-20090105477-A1 | Quinazoline Protein Tyrosine Phosphatase Inhibitors | BERTHEL STEVEN JOSEPH | 2009-04-23 | — | — | US | disclosed |
| US-20090105477-A1 | Quinazoline Protein Tyrosine Phosphatase Inhibitors | BERTHEL STEVEN JOSEPH | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105477-A1 | Quinazoline Protein Tyrosine Phosphatase Inhibitors | PTPN5, PTPN1, PTPN7 | DHFR 2071/4885TRIM58 2337/4885HRH4 3834/4885 |
| US-20060211715-A1 | Quinazoline protein tyrosine phosphatase inhibitors | PTPN5, PTPN1, PTPN7 | DHFR 2071/4885TRIM58 2337/4885HRH4 3834/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.