⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10694736 | 0.83 | — | — | |
| Formaldehyde SCHEMBL6118438 | 0.80 | LMNA (0.44) | — | |
| SCHEMBL27023 | 0.80 | — | — | |
| SCHEMBL4816014 | 0.80 | LMNA (0.50) | — | |
| SCHEMBL5969834 | 0.78 | — | — | |
| Ammonia Solution, Strong SCHEMBL7262621 | 0.76 | LMNA (0.47) | — | |
| Water SCHEMBL9703549 | 0.76 | LMNA (0.47) | — | |
| SCHEMBL4015593 | 0.76 | LMNA (0.47) | — | |
| SCHEMBL667660 | 0.76 | LMNA (0.47) | — | |
| Water SCHEMBL11785760 | 0.76 | LMNA (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150307573-A1 | CYLINDRINS AS ETIOLOGIC AGENTS OF AMYLOID DISEASES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-10-29 | — | — | US | disclosed |
| WO-2013110080-A1 | CYLINDRINS AS ETIOLOGIC AGENTS OF AMYLOID DISEASES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-07-25 | — | — | WO | disclosed |
| US-7626022-B2 | Racemic mixtures; oxidation; cyclization; crystallization | CHIRACON GMBH (DE) | 2009-12-01 | — | — | US | disclosed |
| US-20050080263-A1 | Method for producing ss-heteroaryl-alpha-alanine compounds using 2-amino-2-(heteroarylmethyl) carboxylic acid compounds | CHIRACON GMBH (DE) | 2005-04-14 | — | — | US | disclosed |