⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL875871 | 0.95 | — | — | |
| Lithium Ion SCHEMBL452900 | 0.91 | — | — | |
| Potassium Ion SCHEMBL27292164 | 0.91 | — | — | |
| SCHEMBL8623348 | 0.62 | — | — | |
| SCHEMBL27553357 | 0.60 | — | — | |
| SCHEMBL9406043 | 0.60 | TSHR (0.89) | — | |
| SCHEMBL5897659 | 0.57 | — | — | |
| SCHEMBL1032640 | 0.57 | — | — | |
| Tert-Butyl Hydroperoxide SCHEMBL3026364 | 0.57 | — | — | |
| SCHEMBL1846035 | 0.57 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2429982-A1 | METHODS OF MAKING LUBIPROSTONE AND INTERMEDIATES THEREOF | Apotex Pharmachem Inc. (CA) | 2012-03-21 | — | — | EP | claimed |
| WO-2010083597-A1 | METHODS OF MAKING LUBIPROSTONE AND INTERMEDIATES THEREOF | APOTEX PHARMACHEM INC. (CA) | 2010-07-29 | — | — | WO | claimed |
| EP-0289307-B1 | OPTICALLY ACTIVE AROMATIC CARBOXYLIC ACID DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1992-07-08 | — | — | EP | claimed |
| EP-0289307-A2 | Optically active aromatic carboxylic acid derivatives and process for producing the same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1988-11-02 | — | — | EP | claimed |
| US-9382272-B2 | Methods of making lubiprostone and intermediates thereof | APOTEX PHARMACHEM INC. (CA) | 2016-07-05 | — | — | US | disclosed |
| US-8632734-B2 | High throughput thermally tempered microreactor devices and methods | CORNING INCORPORATED (US) | 2014-01-21 | — | — | US | disclosed |
| EP-2429982-A1 | METHODS OF MAKING LUBIPROSTONE AND INTERMEDIATES THEREOF | Apotex Pharmachem Inc. (CA) | 2012-03-21 | — | — | EP | disclosed |
| US-20120065409-A1 | METHODS OF MAKING LUBIPROSTONE AND INTERMEDIATES THEREOF | APOTEX PHARMACHEM INC. (CA) | 2012-03-15 | — | — | US | disclosed |
| EP-2275198-A1 | Microfluidic manifold devices | Corning Incorporated (US) | 2011-01-19 | — | — | EP | disclosed |
| EP-2266690-A1 | High throughput thermally tempered microreactor devices and methods | Corning Incorporated (US) | 2010-12-29 | — | — | EP | disclosed |
| EP-2263789-A1 | High throughput thermally tempered microreactor devices and methods | Corning Incorporated (US) | 2010-12-22 | — | — | EP | disclosed |
| WO-2010083597-A1 | METHODS OF MAKING LUBIPROSTONE AND INTERMEDIATES THEREOF | APOTEX PHARMACHEM INC. (CA) | 2010-07-29 | — | — | WO | disclosed |
| US-5274168-A | Optically active benzene derivatives, process for producing the same and liquid-crystalline substances containing said derivatives as active ingredient and optical switching elements | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1993-12-28 | — | — | US | disclosed |
| EP-0284371-B1 | NOVEL OPTICALLY ACTIVE BENZENE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND LIQUID-CRYSTALLINE SUBSTANCES CONTAINING SAID DERIVATIVES AS ACTIVE INGREDIENT AND OPTICAL SWITCHING ELEMENTS | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1992-09-16 | — | — | EP | disclosed |
| EP-0493760-A1 | Process for the removal of olefinic impurities from partially halogenated fluorochlorocarbons | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-07-08 | — | — | EP | disclosed |
| US-5002693-A | Novel optically active benzene derivatives, process for producing the same and liquid-crystalline substances containing said derivatives as active ingredient and optical switching elements | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1991-03-26 | — | — | US | disclosed |
| EP-0353732-A2 | Fluoro-olefins, method for their preparation and their use | CIBA-GEIGY AG (CH) | 1990-02-07 | — | — | EP | disclosed |
| US-4078081-A | Cyclopentane derivatives manufacture | HOECHST AKTIENGESELLSCHAFT (DT) | 1978-03-07 | — | — | US | disclosed |
| US-3965120-A | Prostaglandin E1 intermediate 3-carboxymethyl-4-methyl-2-1-carboxy-7-(loweralkoxy or aralkoxycarbonyl)-heptyl]-4-hydroxybutyric acid, γ-lactone, and processes of their preparation | MERCK & CO., INC. (US) | 1976-06-22 | — | — | US | disclosed |
| US-3939182-A | Prostaglandin E1 intermediate 6α-carboxy-5α(1-hydroxyethyl)-2-cyclohexene-1-heptanoic acid,γ-lactone, and lower alkyl or aralkyl esters thereof | MERCK & CO., INC. (US) | 1976-02-17 | — | — | US | disclosed |