Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7153729 | 0.85 | ALDH1A1 (0.61) | ALDH1A1CHRNB2CHRNB4CHRNA4LMNA | |
| Hydrochloric Acid SCHEMBL6214818 | 0.83 | ALDH1A1 (0.58) | ALDH1A1CHRNB2CHRNB4CHRNA4LMNA | |
| Trifluoroacetic Acid SCHEMBL30169296 | 0.83 | SLC22A6 (0.38) | ALDH1A1HDAC6FAAHNOS1NOS2 | |
| Trifluoroacetic Acid SCHEMBL30882498 | 0.83 | SLC22A6 (0.38) | ALDH1A1HDAC6FAAHNOS1NOS2 | |
| SCHEMBL1291925 | 0.81 | ALDH1A1 (0.61) | ALDH1A1CHRNB2CHRNB4CHRNA4LMNA | |
| Trifluoroacetic Acid SCHEMBL1329793 | 0.80 | ALDH1A1 (0.40) | ALDH1A1CHRNB2CHRNB4CHRNA4CHRM2 | |
| Trifluoroacetic Acid SCHEMBL6886600 | 0.80 | NOS1 (0.33) | ALDH1A1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL15254336 | 0.79 | ALDH1A1 (0.58) | ALDH1A1CHRNB2CHRNB4CHRNA4FAAH | |
| SCHEMBL1160178 | 0.79 | ALDH1A1 (0.58) | ALDH1A1CHRNB2CHRNB4CHRNA4FAAH | |
| Hydrochloric Acid SCHEMBL19873292 | 0.79 | ALDH1A1 (0.58) | ALDH1A1CHRNB2CHRNB4CHRNA4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090326003-A1 | PYRAZOLO (3, 4-B) PYRIDINE DERIVATIVES AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090326003-A1 | PYRAZOLO (3, 4-B) PYRIDINE DERIVATIVES AS PDE4 INHIBITORS | PDE4A, PDE4B, PDE12 | ALDH1A1 692/4885CHRNB2 2228/4885CHRNB4 551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.