Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.86 |
| ▸ | DRD2 | P14416 | 7/20 | 0.68 |
| ▸ | HTR1A | P08908 | 12/20 | 0.67 |
| ▸ | HTR7 | P34969 | 5/20 | 0.61 |
| ▸ | HTR2A | P28223 | 4/20 | 0.61 |
| ▸ | HTR6 | P50406 | 3/20 | 0.61 |
| ▸ | DRD4 | P21917 | 2/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.58 |
| ▸ | HRH2 | P25021 | 1/20 | 0.58 |
| ▸ | HTR1B | P28222 | 1/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.58 |
| ▸ | HRH1 | P35367 | 1/20 | 0.58 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.58 |
| ▸ | HTR2B | P41595 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
| ▸ | DRD1 | P21728 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27895403 | 0.99 | KCNH2 (0.84) | KCNH2DRD2HTR1AHTR7HTR2A | |
| SCHEMBL27906495 | 0.94 | KCNH2 (0.81) | KCNH2DRD2HTR1AHTR7HTR2A | |
| SCHEMBL4525293 | 0.93 | KCNH2 (1.00) | KCNH2DRD2HTR1AHTR7HTR2A | |
| SCHEMBL4536392 | 0.86 | KCNH2 (0.86) | KCNH2DRD2HTR1AHTR7HTR2A | |
| SCHEMBL4524281 | 0.85 | KCNH2 (1.00) | KCNH2DRD2HTR1ADRD4 | |
| SCHEMBL3198597 | 0.85 | KCNH2 (0.84) | KCNH2DRD2HTR1AHTR7HTR2A | |
| SCHEMBL30873546 | 0.85 | KCNH2 (0.84) | KCNH2DRD2HTR1AHTR7HTR2A | |
| Hydrochloric Acid SCHEMBL3212440 | 0.84 | KCNH2 (0.82) | KCNH2DRD2HTR1AHTR7HTR2A | |
| SCHEMBL8785239 | 0.83 | KCNH2 (0.81) | KCNH2DRD2HTR1AHTR7HTR2A | |
| SCHEMBL10835591 | 0.83 | KCNH2 (0.81) | KCNH2DRD2HTR1AHTR7HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102875477-A | Phenyl piperazinepyridazinone and preparation method as well as application thereof | UNIV SOUTHERN MEDICAL | 2013-01-16 | — | — | CN | disclosed |
| US-20090238761-A1 | Novel Aryl Piperazine Derivatives With Medical Utility | UNIVERSITA DEGLI STUDI DI SIENA (IT) | 2009-09-24 | — | — | US | disclosed |
| EP-1836192-A2 | ARYL PIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS | Universita' Degli Studi di Siena (IT) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006072608-A2 | ARYL PIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS | UNIVERSITÁ DEGLI STUDI DI SIENA (IT) | 2006-07-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090238761-A1 | Novel Aryl Piperazine Derivatives With Medical Utility | HTR2C, HTR2A, DRD2 | KCNH2 769/4885DRD2 3/4885HTR1A 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.