Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 8/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.36 |
| ▸ | HSD11B2 | P80365 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4539384 | 0.83 | HPGD (0.54) | HPGDPOLBHSD11B1ALDH1A1HTT | |
| SCHEMBL4534788 | 0.82 | HPGD (0.57) | HPGDPOLBHSD11B1HTTHSD11B2 | |
| SCHEMBL4538193 | 0.73 | HPGD (0.55) | HPGDPOLBHSD11B1ALDH1A1HTT | |
| SCHEMBL4540367 | 0.72 | HSD11B1 (0.50) | HPGDPOLBHSD11B1ALDH1A1HTT | |
| SCHEMBL14030255 | 0.71 | POLB (0.58) | HPGDPOLBHSD11B1ALDH1A1HTT | |
| SCHEMBL14030375 | 0.71 | POLB (0.58) | HPGDPOLBHSD11B1ALDH1A1HTT | |
| SCHEMBL4539612 | 0.71 | POLB (0.48) | HPGDPOLBHSD11B1ALDH1A1HTT | |
| SCHEMBL14030286 | 0.70 | POLB (0.55) | HPGDPOLBHSD11B1ALDH1A1HTT | |
| SCHEMBL4540694 | 0.68 | HPGD (0.57) | HPGDPOLBHSD11B1ALDH1A1HTT | |
| SCHEMBL4536746 | 0.68 | POLB (0.50) | HPGDPOLBHSD11B1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009073460-A2 | INHIBITION OF 11 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 FOR OCULAR NEUROPROTECTION | BAUSCH & LOMB INCORPORATED (US) | 2009-06-11 | — | — | WO | disclosed |
| US-7179802-B2 | 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia | MERCK & CO., INC. (US) | 2007-02-20 | — | — | US | disclosed |
| US-7179802-B2 | 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia | MERCK & CO., INC. (US) | 2007-02-20 | — | — | US | disclosed |
| US-7179802-B2 | 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia | MERCK & CO., INC. (US) | 2007-02-20 | — | — | US | disclosed |