Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.50 |
| ▸ | HSD11B2 | P80365 | 2/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4539384 | 0.87 | HPGD (0.54) | HPGDHTTHSD11B1HSD11B2POLB | |
| SCHEMBL4530537 | 0.82 | HPGD (0.41) | HPGDHTTHSD11B1HSD11B2POLB | |
| SCHEMBL12020354 | 0.80 | HPGD (0.47) | HPGDHTTHSD11B1HSD11B2NR1I2 | |
| SCHEMBL4538193 | 0.77 | HPGD (0.55) | HPGDHTTHSD11B1HSD11B2POLB | |
| SCHEMBL4540367 | 0.76 | HSD11B1 (0.50) | HPGDHTTHSD11B1HSD11B2POLB | |
| SCHEMBL14030255 | 0.75 | POLB (0.58) | HPGDHTTHSD11B1HSD11B2POLB | |
| SCHEMBL14030375 | 0.75 | POLB (0.58) | HPGDHTTHSD11B1HSD11B2POLB | |
| SCHEMBL14030286 | 0.73 | POLB (0.55) | HPGDHTTHSD11B1HSD11B2POLB | |
| SCHEMBL2858672 | 0.73 | HPGD (1.00) | HPGDHTTHSD11B1HSD11B2NR1I2 | |
| SCHEMBL4540694 | 0.72 | HPGD (0.57) | HPGDHTTHSD11B1HSD11B2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009073460-A2 | INHIBITION OF 11 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 FOR OCULAR NEUROPROTECTION | BAUSCH & LOMB INCORPORATED (US) | 2009-06-11 | — | — | WO | disclosed |
| US-7179802-B2 | 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia | MERCK & CO., INC. (US) | 2007-02-20 | — | — | US | disclosed |
| US-7179802-B2 | 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia | MERCK & CO., INC. (US) | 2007-02-20 | — | — | US | disclosed |
| US-7179802-B2 | 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia | MERCK & CO., INC. (US) | 2007-02-20 | — | — | US | disclosed |