SCHEMBL4535495

SCHEMBL4535495

COc1cc(Nc2cc(C3(C)C=NC4=C3C(=O)CCC4)ccc2C(N)=O)cc(OC)c1OC

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 6/20 0.51
HSP90AB1 P08238 6/20 0.51
MAPK9 P45984 2/20 0.42
MAPK10 P53779 1/20 0.42
SYK P43405 1/20 0.40
PTK2 Q05397 4/20 0.36
JAK2 O60674 2/20 0.36
TYK2 P29597 2/20 0.36
JAK3 P52333 2/20 0.36
CDC7 O00311 1/20 0.36
PLK4 O00444 1/20 0.36
CHEK1 O14757 1/20 0.36
DCLK1 O15075 1/20 0.36
CHUK O15111 1/20 0.36
PDPK1 O15530 1/20 0.36
DAPK3 O43293 1/20 0.36
DYRK3 O43781 1/20 0.36
ROCK2 O75116 1/20 0.36
PRKD3 O94806 1/20 0.36
MAP4K4 O95819 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4526380 0.88 HSP90AA1 (0.55) HSP90AA1HSP90AB1MAPK9MAPK10SYK
SCHEMBL4531034 0.86 HSP90AA1 (0.42) HSP90AA1HSP90AB1JAK2TYK2JAK3
SCHEMBL4536660 0.73 KDM4E (0.44) JAK2JAK3CDC7ROCK2MAP4K4
SCHEMBL4534406 0.71 HSP90AA1 (0.35) HSP90AA1HSP90AB1
SCHEMBL13450261 0.69 MAPK9 (0.57) HSP90AA1HSP90AB1MAPK9MAPK10SYK
SCHEMBL1220363 0.69 HSP90AA1 (0.75) HSP90AA1HSP90AB1MAPK9MAPK10SYK
SCHEMBL1219093 0.69 HSP90AA1 (0.75) HSP90AA1HSP90AB1MAPK9MAPK10SYK
SCHEMBL1219051 0.68 HSP90AA1 (1.00) HSP90AA1HSP90AB1MAPK9MAPK10SYK
SCHEMBL2423506 0.67 MAPK9 (0.55) HSP90AA1HSP90AB1MAPK9MAPK10SYK
SCHEMBL4523815 0.67 MAPK9 (0.76) MAPK9MAPK10PTK2JAK2TYK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4377942-B2 2009-12-02 JP claimed
JP-2008531599-A 2008-08-14 JP claimed
EP-1856057-A1 TETRAHYDROINDOLONE AND TETRAHYDROINDAZOLONE DERIVATIVES Serenex, Inc. (US) 2007-11-21 EP claimed
WO-2006091963-A1 TETRAHYDROINDOLONE AND TETRAHYDROINDAZOLONE DERIVATIVES SERENEX, INC. (US) 2006-08-31 WO claimed