Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.70 |
| ▸ | ROCK2 | O75116 | 10/20 | 0.68 |
| ▸ | ROCK1 | Q13464 | 9/20 | 0.68 |
| ▸ | FLT3 | P36888 | 2/20 | 0.67 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.67 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.67 |
| ▸ | CDK1 | P06493 | 1/20 | 0.67 |
| ▸ | CSF1R | P07333 | 1/20 | 0.67 |
| ▸ | PRKACA | P17612 | 1/20 | 0.67 |
| ▸ | FLT1 | P17948 | 1/20 | 0.67 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.67 |
| ▸ | CDK2 | P24941 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | AKT1 | P31749 | 1/20 | 0.67 |
| ▸ | FLT4 | P35916 | 1/20 | 0.67 |
| ▸ | KDR | P35968 | 1/20 | 0.67 |
| ▸ | GSK3A | P49840 | 1/20 | 0.67 |
| ▸ | GSK3B | P49841 | 1/20 | 0.67 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.67 |
| ▸ | PRKX | P51817 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4519247 | 1.00 | HSD17B10 (0.70) | HSD17B10ROCK2ROCK1FLT3RPS6KA5 | |
| SCHEMBL11615932 | 0.88 | HSD17B10 (0.79) | HSD17B10ROCK2ROCK1FLT3RPS6KA5 | |
| SCHEMBL15141127 | 0.85 | ROCK2 (0.67) | HSD17B10ROCK2ROCK1FLT3RPS6KA5 | |
| SCHEMBL9306563 | 0.83 | HSD17B10 (1.00) | HSD17B10FLT3CLK4NAMPTCYP2C9 | |
| SCHEMBL9306555 | 0.83 | HSD17B10 (1.00) | HSD17B10FLT3CLK4NAMPTCYP2C9 | |
| SCHEMBL4529785 | 0.83 | ROCK2 (0.68) | HSD17B10ROCK2ROCK1FLT3RPS6KA5 | |
| SCHEMBL4533295 | 0.83 | ROCK2 (0.68) | HSD17B10ROCK2ROCK1FLT3RPS6KA5 | |
| SCHEMBL28286785 | 0.82 | ROCK2 (0.65) | ROCK2ROCK1NAMPTCYP3A4CYP3A5 | |
| SCHEMBL10259303 | 0.82 | ROCK2 (0.62) | HSD17B10ROCK2ROCK1FLT3RPS6KA5 | |
| SCHEMBL10259736 | 0.82 | ROCK2 (0.62) | HSD17B10ROCK2ROCK1FLT3RPS6KA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8211919-B2 | Amide derivatives as rock inhibitors | ASTELLAS PHARMA INC. (JP) | 2012-07-03 | — | — | US | disclosed |
| US-8211919-B2 | Amide derivatives as rock inhibitors | ASTELLAS PHARMA INC. (JP) | 2012-07-03 | — | — | US | disclosed |
| US-8211919-B2 | Amide derivatives as rock inhibitors | ASTELLAS PHARMA INC. (JP) | 2012-07-03 | — | — | US | disclosed |
| US-20090105231-A1 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2009-04-23 | — | — | US | disclosed |
| US-20090105231-A1 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2009-04-23 | — | — | US | disclosed |
| US-20090105231-A1 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105231-A1 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ROCK1, ROCK2, RHOA | HSD17B10 1985/4885ROCK2 2/4885ROCK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.