Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 9/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7080108 | 0.95 | EPHX1 (0.41) | EPHX1CES2CES1ALOX5NPC1 | |
| SCHEMBL29013937 | 0.93 | EPHX1 (0.39) | EPHX1CES2CES1ALOX5NPC1 | |
| SCHEMBL27960380 | 0.93 | EPHX1 (0.37) | EPHX1CES2CES1ALOX5KEAP1 | |
| Hydrochloric Acid SCHEMBL4532336 | 0.91 | EPHX1 (0.38) | EPHX1CES2CES1ALOX5NPC1 | |
| SCHEMBL27844046 | 0.88 | EPHX1 (0.37) | EPHX1CES2CES1ALOX5NPC1 | |
| SCHEMBL27573596 | 0.86 | EPHX1 (0.35) | EPHX1CES2CES1ALOX5SSTR4 | |
| SCHEMBL28465427 | 0.86 | EPHX1 (0.38) | EPHX1CES2CES1ALOX5NPC1 | |
| SCHEMBL7078828 | 0.82 | EPHX1 (0.35) | EPHX1CES2CES1ALOX5NPC1 | |
| SCHEMBL28905469 | 0.77 | TSHR (0.38) | EPHX1ALOX5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2842403 | 0.75 | EPHX1 (0.41) | EPHX1CES2CES1ALOX5NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013047891-A2 | WASHING METHOD, ADDITION POLYMERIZATION METHOD, PREPOLYMERIZATION METHOD, PREPOLYMERIZED CATALYTIC COMPONENT FOR ADDITION POLYMERIZATION, AND METHOD FOR PRODUCING ADDITION POLYMER USING THE SAME | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2013-04-04 | — | — | WO | disclosed |
| WO-2012063972-A1 | METHOD FOR COATING REACTOR | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-05-18 | — | — | WO | disclosed |
| CN-1496996-A | Modified granular, addition polymerized catalyst composition, addition polymerization catalyst and method of producing addition polymerization product | ס�ѻ�ѧ��ҵ��ʽ���� | 2004-05-19 | — | — | CN | disclosed |