SCHEMBL45328

SCHEMBL45328

c1ccc2c(c1)CN=NS2

nearest known ligand 0.31

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
RYR2 Q92736 1/20 0.31
KDM4E B2RXH2 1/20 0.31
ALDH1A1 P00352 1/20 0.31
HPGD P15428 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL757802 0.76
SCHEMBL3633989 0.71
SCHEMBL29657670 0.68 TSHR (0.42)
SCHEMBL1420960 0.68 TSHR (0.42)
SCHEMBL6628694 0.67 KCNJ1 (0.35) KDM4EALDH1A1HPGD
SCHEMBL11807290 0.67
SCHEMBL8275 0.64 RYR2 (0.31) RYR2KDM4EALDH1A1HPGD
SCHEMBL1119362 0.64 PLAU (0.38) RYR2KDM4EALDH1A1HPGD
SCHEMBL3081411 0.64 ALDH1A1 (0.38) RYR2KDM4EALDH1A1HPGD
SCHEMBL1386398 0.64 RYR2 (0.31) RYR2KDM4EALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 6887 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026087680-A1 TREATMENT FOR CARDIOVASCULAR DISEASE SAPREME TECHNOLOGIES B.V. (NL) 2026-04-30 WO claimed
US-12605384-B2 Uses INTRA-CELLULAR THERAPIES, INC. (US) 2026-04-21 US claimed
WO-2025111482-A1 COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS BEXSON BIOMEDICAL, INC. (US) 2025-05-30 WO claimed
CN-120037437-A Polyvinyl alcohol embolism microsphere with photodynamic effect and preparation method thereof 南京邮电大学 2025-05-27 CN claimed
CN-115792063-B Method for detecting related substances of olmesartan medoxomil hydrochlorothiazide tablets 珠海润都制药股份有限公司 2025-04-04 CN claimed
CN-118979403-A Preparation method of offset printing paper 齐鲁工业大学(山东省科学院) 2024-11-19 CN claimed
CN-118743361-A Plant protection film and preparation method and application thereof 四川嘉智生态科技有限公司 2024-10-08 CN claimed
CN-118614539-A Synergistic treatment method for promoting rapid healing of mechanical injury of sweet potato tuberous root 四川农业大学 2024-09-10 CN claimed
US-20240172753-A1 AGRICULTURAL FORMULATIONS STEPAN COMPANY 2024-05-30 US claimed
CN-117946012-A Preparation method of nitrogen-containing heterocycle 温州理工学院 2024-04-30 CN claimed
EP-0100061-A2 Pharmaceutical combination composition and associated method Mylan Pharmaceuticals, Inc. (US) 1984-02-08 EP claimed
EP-0083779-A1 Hyperuretic agents Beyer, Karl H., Jr. (US) 1983-07-20 EP claimed
EP-0011818-B1 MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS BASED ON ALDOSTERONE ANTAGONISTS AND DIURETICS AND PROCESS FOR THEIR MANUFACTURE CIBA-GEIGY AG (CH) 1983-01-19 EP claimed
US-4261985-A REDUCED EXCRETION OF POTASSIUM IONS BY INCLUSION OF ALDOSTERONE ANTAGONIST CIBA-GEIGY CORPORATION (US) 1981-04-14 US claimed
US-4238485-A 1,2,5-THIADIAZOLE DERIVATIVE, THIAZIDE DIURETIC, HYPOTENSIVE AGENTS MERCK & CO., INC. (US) 1980-12-09 US claimed
EP-0011818-A1 Medicaments and pharmaceutical compositions based on aldosterone antagonists and diuretics and process for their manufacture CIBA-GEIGY AG (CH) 1980-06-11 EP claimed
US-4104381-A HISTAMINE INHIBITORS, ((IMIDAZOLYLALKYL)AMINO)THIADIAZINES SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1978-08-01 US claimed
US-4045306-A REACTION PRODUCT OF UNSATURATED NITROGEN HETEROCYCLIC COMPOUND AND A HALOHYDRIN SCHERING AKTIENGESELLSCHAFT (DT) 1977-08-30 US claimed
US-3988324-A XANTHINE OXIDASE INHIBITORS MERCK & CO., INC. (US) 1976-10-26 US claimed
US-3951966-A XANTHINE OXIDASE INHIBITORS MERCK & CO., INC. (US) 1976-04-20 US claimed